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01-06-2013

Mycophenolate Mofetil Has Potent Anti-inflammatory Actions in a Mouse Model of Acute Lung Injury

Authors: M. G. Beduschi, C. L. Guimarães, Z. S. Buss, E. M. Dalmarco

Published in: Inflammation | Issue 3/2013

Abstract

Septic shock is a systemic inflammatory response syndrome, and it is the leading cause of death in intensive care units. Mycophenolate mofetil (MMF) is an immunosuppressant that has been shown to be effective in the treatment of various inflammatory diseases. In this study, the anti-inflammatory effect of MMF in a mouse model of acute lung injury (ALI) induced by lipopolysaccharide (LPS) was evaluated. ALI was induced by intrapleural injection of LPS (250 ng/cavity). The leukocyte migration, exudation, myeloperoxidase and adenosine deaminase activities, nitric oxide products, tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β) levels, as well as mRNA expression of TNF-α and IL-1β, were evaluated. This study showed that MMF significantly decreased all parameters studied in a manner comparable to treatment with dexamethasone. In conclusion, MMF has important anti-inflammatory effects that may be useful as an auxiliary treatment for septic shock.

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Title: Mycophenolate Mofetil Has Potent Anti-inflammatory Actions in a Mouse Model of Acute Lung Injury
Authors: M. G. Beduschi
C. L. Guimarães
Z. S. Buss
E. M. Dalmarco
Publication date: 01-06-2013
Publisher: Springer US
Published in: Inflammation / Issue 3/2013
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-013-9599-x

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