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Published in: Inflammopharmacology 1/2020

01-02-2020 | Myasthenia Gravis | Review

Therapeutic potential of aryl hydrocarbon receptor in autoimmunity

Authors: Xiao-Song Wang, Fan Cao, Yi Zhang, Hai-Feng Pan

Published in: Inflammopharmacology | Issue 1/2020

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Abstract

Aryl hydrocarbon receptor (AhR), a type of transcriptional factor, is widely expressed in immune cells. The activation of AhR signaling pathway depends on its ligands, which exist in environment and can also be produced by metabolism. Normal expressions of AhR and AhR-mediated signaling may be essential for immune responses, and effects of AhR signaling on the development and function of innate and adaptive immune cells have also been revealed in previous studies. Recent studies also indicate that aberrant AhR signaling may be related to autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), autoimmune uveitis (AU), autoimmune diabetes, Behcet’s disease (BD) and myasthenia gravis (MG). Moreover, administration of AhR ligands or drugs has been proven effective for improving pathological outcomes in some autoimmune diseases or models. In this review, we summarize the effects of AhR on several innate and adaptive immune cells associated with autoimmunity, and the mechanism on how AhR participates in autoimmune diseases. In addition, we also discuss therapeutic potential and application prospect of AhR in autoimmune diseases, so as to provide valuable information for exploring novel and effective approaches to autoimmune disease treatments.
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Metadata
Title
Therapeutic potential of aryl hydrocarbon receptor in autoimmunity
Authors
Xiao-Song Wang
Fan Cao
Yi Zhang
Hai-Feng Pan
Publication date
01-02-2020
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 1/2020
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-019-00651-z

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