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European Journal of Nuclear Medicine and Molecular Imaging

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01-02-2020 | Multiple Sclerosis | Original Article

Repurposing radiotracers for myelin imaging: a study comparing 18F-florbetaben, 18F-florbetapir, 18F-flutemetamol,11C-MeDAS, and 11C-PiB

Authors: Sylvain Auvity, Matteo Tonietto, Fabien Caillé, Benedetta Bodini, Michel Bottlaender, Nicolas Tournier, Bertrand Kuhnast, Bruno Stankoff

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2020

Abstract

Purpose

Drugs promoting myelin repair represent a promising therapeutic approach in multiple sclerosis and several candidate molecules are currently being evaluated, fostering the need of a quantitative method to specifically measure myelin content in vivo. PET using the benzothiazole derivative ¹¹C-PiB has been successfully used to quantify myelin content changes in humans. Stilbene derivatives, such as ¹¹C-MeDAS, have also been shown to bind to myelin in animals and are considered a promising radiopharmaceutical class for myelin imaging. Fluorinated compounds from both classes are now commercially available and thus should constitute clinically useful myelin radiotracers. The aim of this study is to provide a head-to-head comparison of ¹⁸F-florbetaben, ¹⁸F-florbetapir, ¹⁸F-flutemetamol, ¹¹C-MeDAS, and ¹¹C-PiB with regard to brain kinetics and binding in white matter (WM).

Methods

Four baboons underwent a 90-min dynamic PET scan for each radioligand. Arterial blood samples were collected during the exam for each radiotracer, except for ¹⁸F-florbetapir, to obtain a radiometabolite-corrected input function. Standardized uptake value ratio between 75 at 90 min (SUVR_75–90), binding potential (BP) estimated with Logan method with input function, and distribution volume ratio (DVR) estimated with Logan reference method (using cerebellar gray matter as reference region) were calculated in WM and compared between tracers using mixed effect models.

Results

In WM, ¹⁸F-florbetapir had the highest SUVR_75–90 (1.38 ± 0.03), followed by ¹⁸F-flutemetamol (1.34 ± 0.02), ¹⁸F-florbetaben (1.32 ± 0.07), ¹¹C-MeDAS (1.27 ± 0.04), and ¹¹C-PiB (1.25 ± 0.07). With regard to BP, ¹⁸F-florbetaben had the highest value (0.32 ± 0.06) compared with ¹⁸F-flutemetamol (0.20 ± 0.03), ¹¹C-MeDAS (0.17 ± 0.03), and ¹¹C-PiB (0.16 ± 0.03). No difference in DVR was detected between ¹⁸F-florbetaben (1.26 ± 0.06) and ¹⁸F-florbetapir (1.27 ± 0.03), but both were significantly higher in DVR than ¹⁸F-flutemetamol (1.17 ± 0.02), ¹¹C-MeDAS (1.16 ± 0.03), and ¹¹C-PiB (1.14 ± 0.02).

Conclusions

Given their higher binding and longer half-life, our study indicates that ¹⁸F-florbetapir and ¹⁸F-florbetaben are promising tracers for myelin imaging which are readily available for clinical application in demyelinating diseases.

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Title: Repurposing radiotracers for myelin imaging: a study comparing 18F-florbetaben, 18F-florbetapir, 18F-flutemetamol,11C-MeDAS, and 11C-PiB
Authors: Sylvain Auvity
Matteo Tonietto
Fabien Caillé
Benedetta Bodini
Michel Bottlaender
Nicolas Tournier
Bertrand Kuhnast
Bruno Stankoff
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Sclerosis
Positron Emission Tomography
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2020
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04516-z

At a glance: The STEP trials

Springer Medicine

Repurposing radiotracers for myelin imaging: a study comparing 18F-florbetaben, 18F-florbetapir, 18F-flutemetamol,11C-MeDAS, and 11C-PiB

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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