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Published in: European Journal of Nuclear Medicine and Molecular Imaging 2/2019

01-02-2019 | Original Article

Amyloid PET as a marker of normal-appearing white matter early damage in multiple sclerosis: correlation with CSF β-amyloid levels and brain volumes

Authors: Anna M. Pietroboni, Tiziana Carandini, Annalisa Colombi, Matteo Mercurio, Laura Ghezzi, Giovanni Giulietti, Marta Scarioni, Andrea Arighi, Chiara Fenoglio, Milena A. De Riz, Giorgio G. Fumagalli, Paola Basilico, Maria Serpente, Marco Bozzali, Elio Scarpini, Daniela Galimberti, Giorgio Marotta

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2019

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Abstract

Purpose

The disease course of multiple sclerosis (MS) is unpredictable, and reliable prognostic biomarkers are needed. Positron emission tomography (PET) with β-amyloid tracers is a promising tool for evaluating white matter (WM) damage and repair. Our aim was to investigate amyloid uptake in damaged (DWM) and normal-appearing WM (NAWM) of MS patients, and to evaluate possible correlations between cerebrospinal fluid (CSF) β-amyloid1-42 (Aβ) levels, amyloid tracer uptake, and brain volumes.

Methods

Twelve MS patients were recruited and divided according to their disease activity into active and non-active groups. All participants underwent neurological examination, neuropsychological testing, lumbar puncture, brain magnetic resonance (MRI) imaging, and 18F-florbetapir PET. Aβ levels were determined in CSF samples from all patients. MRI and PET images were co-registered, and mean standardized uptake values (SUV) were calculated for each patient in the NAWM and in the DWM. To calculate brain volumes, brain segmentation was performed using statistical parametric mapping software. Nonparametric statistical analyses for between-group comparisons and regression analyses were conducted.

Results

We found a lower SUV in DWM compared to NAWM (p < 0.001) in all patients. Decreased NAWM-SUV was observed in the active compared to non-active group (p < 0.05). Considering only active patients, NAWM volume correlated with NAWM-SUV (p = 0.01). Interestingly, CSF Aβ concentration was a predictor of both NAWM-SUV (r = 0.79; p = 0.01) and NAWM volume (r = 0.81, p = 0.01).

Conclusions

The correlation between CSF Aβ levels and NAWM-SUV suggests that the predictive role of β-amyloid may be linked to early myelin damage and may reflect disease activity and clinical progression.
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Metadata
Title
Amyloid PET as a marker of normal-appearing white matter early damage in multiple sclerosis: correlation with CSF β-amyloid levels and brain volumes
Authors
Anna M. Pietroboni
Tiziana Carandini
Annalisa Colombi
Matteo Mercurio
Laura Ghezzi
Giovanni Giulietti
Marta Scarioni
Andrea Arighi
Chiara Fenoglio
Milena A. De Riz
Giorgio G. Fumagalli
Paola Basilico
Maria Serpente
Marco Bozzali
Elio Scarpini
Daniela Galimberti
Giorgio Marotta
Publication date
01-02-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-018-4182-1

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