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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-07-2020 | Multiple Sclerosis | Neurophthalmology

Optic neuritis in German children: clinical findings and association with multiple sclerosis

Authors: Felix Tonagel, Helmut Wilhelm, Carina Kelbsch

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2020

Abstract

Purpose

Analysis of a cohort of pediatric optic neuritis patients concerning the epidemiology, disease progression, and association with multiple sclerosis (MS).

Methods

Retrospective, observational cohort study. From 2004 to 2018, all electronic medical files of patients younger than 18 years referred to a tertiary care clinic in Germany with the diagnosis optic neuritis have been analyzed.

Results

Sixty-nine patients were referred in the study period, 16 did not suffer under optic neuritis and were excluded. The median visual acuity of the remaining 53 patients was 0.07 at the baseline examination and 1.0 at the latest follow-up examination (decimal notation, median 2.1 years after baseline). Forty-two percent of the patients developed MS during the study period. Female sex (p = 0.028) as well as higher age (p = 0.0082) proved to be statistically significant risk factors for MS development.

Conclusion

The prognosis for restoring vision in pediatric optic neuritis was favorable. During the observation period, the risk of developing MS was overall 42% and 8% for patients younger than 11 years. The percentage of MS as underlying cause of optic neuritis does not differ remarkably between children older 10 years and adults.

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Title: Optic neuritis in German children: clinical findings and association with multiple sclerosis
Authors: Felix Tonagel
Helmut Wilhelm
Carina Kelbsch
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Sclerosis
Optic Neuritis
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04669-w

At a glance: The STEP trials

Springer Medicine

Optic neuritis in German children: clinical findings and association with multiple sclerosis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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