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The Journal of Obstetrics and Gynecology of India

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07-06-2023 | Multiple Pregnancy | Original Article

Elective Single Cleavage-Stage Embryo Transfer in IVF Patients with Suboptimal Ovarian Response is Not Detrimental to Cumulative Pregnancy and Reduces Multiple Pregnancy Rates.

Authors: Alessio Paffoni, Sabrina Cesana, Laura Corti, Hilda Wyssling, Alessandro Kunderfranco, Marco Claudio Bianchi

Published in: The Journal of Obstetrics and Gynecology of India | Issue 4/2023

Abstract

Purpose

To evaluate whether elective single embryo transfer in patients with suboptimal response to ovarian stimulation is detrimental to pregnancy rates compared to double embryo transfer.

Methods

A case–control retrospective study was performed in a cohort of couples undergoing IVF at the Infertility Unit of the ASST Lariana with ≤ 9 oocytes and at least 2 viable embryos. A total of 424 women were analyzed in the “double embryo transfer” group (n = 212) and elective “single embryo transfer” group (n = 212); they were matched 1:1 for female age, ovarian reserve and number of previous cycles. Cumulative clinical pregnancy rate per oocyte retrieval was the main outcome.

Results

The cumulative pregnancy rate per cycle, including the fresh embryo and subsequent frozen embryo transfers, was 26% and 26%, respectively. Considering the main confounding factors, a binomial logistic model indicated that the cumulative clinical pregnancy rate was not significantly affected when a single embryo transfer was performed in women recovering up to nine oocytes.

Conclusion

Live birth rate was similar between the two groups, while twin pregnancies were significantly reduced in women receiving single embryo transfer suggesting that elective single embryo transfer in patients with a limited number of embryos is not detrimental to pregnancy rates.

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Title: Elective Single Cleavage-Stage Embryo Transfer in IVF Patients with Suboptimal Ovarian Response is Not Detrimental to Cumulative Pregnancy and Reduces Multiple Pregnancy Rates.
Authors: Alessio Paffoni
Sabrina Cesana
Laura Corti
Hilda Wyssling
Alessandro Kunderfranco
Marco Claudio Bianchi
Publication date: 07-06-2023
Publisher: Springer India
Keyword: Multiple Pregnancy
Published in: The Journal of Obstetrics and Gynecology of India / Issue 4/2023
Print ISSN: 0971-9202
Electronic ISSN: 0975-6434
DOI: https://doi.org/10.1007/s13224-023-01768-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Elective Single Cleavage-Stage Embryo Transfer in IVF Patients with Suboptimal Ovarian Response is Not Detrimental to Cumulative Pregnancy and Reduces Multiple Pregnancy Rates.

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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