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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2004

01-04-2004 | Review

Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases

Authors: Monika C Brunner-Weinzierl, Holger Hoff, Gerd-R Burmester

Published in: Arthritis Research & Therapy | Issue 2/2004

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Abstract

Chronic T cell responses, as they occur in rheumatoid arthritis, are complex and are likely to involve many mechanisms. There is a growing body of evidence that, in concert with the T cell antigen receptor signal, CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152) are the primary regulators of T cell responses. Whereas CD28 primarily activates T cell processes, CTLA-4 inhibits them. The mechanism for this dichotomy is not fully understood, especially as CD28 and CTLA-4 recruit similar signalling molecules. In addition, recent studies demonstrate that CD28 and CTLA-4 have multiple functions during T cell responses. In particular, CTLA-4 exerts independent distinct effects during different phases of T cell responses that could be exploited for the treatment of rheumatoid arthritis.
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Metadata
Title
Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases
Authors
Monika C Brunner-Weinzierl
Holger Hoff
Gerd-R Burmester
Publication date
01-04-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1158

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