Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Child's Nervous System
Published in: Child's Nervous System 8/2013

01-08-2013 | Case-Based Update

Multiple cerebral abscesses in Papillon–Lefèvre syndrome

Authors: Hari Krishnan Kanthimathinathan, Fiona Browne, Roberto Ramirez, Sarah McKaig, Geoff Debelle, Jeff Martin, Iain L C Chapple, Andrew Kay, Celia Moss

Published in: Child's Nervous System | Issue 8/2013

Login to get access

Abstract

Papillon–Lefèvre syndrome is characterised by palmoplantar keratoderma, periodontitis and pyogenic infections. We describe the first case of brain abscess in a child with this syndrome. We highlight the importance of recognising any associated diagnosis, however rare or apparently irrelevant, in an acutely and critically ill child.
Literature
1.
Keskin-Yildirim Z, Simşek-Derelioğlu S, Kantarci M, Yilmaz Y, Büyükavci M (2012) Papillon–Lefèvre syndrome: report of three cases in the same family. Turk J Pediatr 54:171–176PubMed
2.
Khan FY, Jan SM, Mushtaq M (2012) Papillon–Lefèvre syndrome: case report and review of the literature. J Indian Soc Periodontol 16:261–265PubMedCrossRef
3.
Dalgic B, Bukulmez A, Sari S (2011) Eponym: Papillon–Lefevre syndrome. Eur J Pediatr 170:689–691PubMedCrossRef
4.
Almuneef M, Al Khenaizan S, Al Ajaji S, Al-Anazi A (2003) Pyogenic liver abscess and Papillon–Lefèvre syndrome: not a rare association. Pediatrics 111:e85–e88PubMedCrossRef
5.
Selvaraju V, Markandaya M, Prasad PV, Sathyan P, Sethuraman G, Srivastava SC et al (2003) Mutation analysis of the cathepsin C gene in Indian families with Papillon–Lefèvre syndrome. BMC Med Genet 4:5PubMedCrossRef
6.
Gorlin RJ, Sedano H, Anderson VE (1964) The syndrome of palmar-plantar hyperkeratosis and premature periodonotal destruction of the teeth. A clinical and genetic analysis of the Papillon–Lefèvre syndrome. J Pediatr 65:895–908PubMedCrossRef
7.
Pallos D, Acevedo AC, Mestrinho HD, Cordeiro I, Hart T (2010) Novel cathepsin C mutation in a Brazilian family with Papillon–Lefèvre syndrome: case report and mutation update. J Dent Child (Chic) 77:36–41
8.
Sørensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS et al (2001) Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97:3951–3959PubMedCrossRef
9.
Taibjee SM, Zhang L, Chapple IL, Thakker N, Moss C (2005) Pyogenic skin infections as a presentation of Papillon–Lefèvre syndrome: phenotypic variability or under-reporting? Periodontal Pract Today 2:191–197
10.
Albandar JM, Khattab R, Monem F, Barbuto SM, Paster BJ (2012) The subgingival microbiota of Papillon–Lefèvre syndrome. J Periodontol 83:902–908PubMedCrossRef
11.
Javaid A, Rehman A, Mannan P (1996) Papillon–Lefevre syndrome presenting as liver and lung abscess. J Postgrad Med Inst (Peshawar-Pakistan) 10:107–109
12.
Morgan RD, Hannon E, Lakhoo K (2011) Renal abscess in Papillion–Lefèvre syndrome. Pediatr Surg Int 27:1381–1383PubMedCrossRef
13.
Koch D, McKaig S, Chapple ILC, Moss C (2009) The effects of oral acitretin therapy in 4 children with Papillon–Lefèvre syndrome. Br J Dermatol 161(Suppl 1):51
Metadata
Title
Multiple cerebral abscesses in Papillon–Lefèvre syndrome
Authors
Hari Krishnan Kanthimathinathan
Fiona Browne
Roberto Ramirez
Sarah McKaig
Geoff Debelle
Jeff Martin
Iain L C Chapple
Andrew Kay
Celia Moss
Publication date
01-08-2013
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 8/2013
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-013-2152-2

Other articles of this Issue 8/2013

Child's Nervous System 8/2013 Go to the issue

Original Paper

Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas

Case Report

A complicated case of plagiocephaly followed by delayed craniosynostosis

Original Paper

A retrospective comparison of CT and MRI in detecting pediatric cervical spine injury

Letter to the Editor

Parental allografts in the management of Adams–Oliver syndrome

Original Paper

Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children

Original Paper

Institutional experience of endoscopic suprasellar arachnoid cyst fenestration