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Antimicrobial Resistance & Infection Control
Published in: Antimicrobial Resistance & Infection Control 1/2014

Open Access 01-12-2014 | Review

Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Authors: Fantahun Biadglegne, Ulrich Sack, Arne C Rodloff

Published in: Antimicrobial Resistance & Infection Control | Issue 1/2014

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Abstract

The emergence of drug-resistant tuberculosis (TB), particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, is a major public health problem. The purpose of this review is to describe the current status of MDR-TB and factors that increase the risk of this infection. We conducted a systematic review of the literature on MDR-TB in Ethiopia. Out of 766 articles, 23 were found to meet eligibility criteria and included in this review. Among the 23 papers, six of them reported high prevalence of MDR-TB in the range of 3.3%-46.3%. Likewise, two studies reported XDR-TB in the range of 1% - 4.4% in Ethiopia. The most powerful predictor of the emergence of MDR-TB reported in Ethiopia is previous exposure to anti-TB drug treatment. This review indicated that MDR-TB in Ethiopia is a serious public health problem that needs to be addressed urgently. Strengthening early case detection and proper treatment of drug-susceptible TB in accordance with World Health Organization (WHO) treatment guidelines to ensure adequate treatment success rates is critical. Consequently, efforts have been made to a rapidly increase MDR-TB diagnosis as well as the number of treatment sites to implement a directly observed treatment, short-course (DOTS) plus strategy to interrupt transmission of MDR-TB.
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Metadata
Title
Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care
Authors
Fantahun Biadglegne
Ulrich Sack
Arne C Rodloff
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Antimicrobial Resistance & Infection Control / Issue 1/2014
Electronic ISSN: 2047-2994
DOI
https://doi.org/10.1186/2047-2994-3-31

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