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Published in: Diagnostic Pathology 1/2008

Open Access 01-12-2008 | Case Report

Mucinous breast carcinoma presenting as Paget's disease of the nipple in a man: A case report

Authors: Dimitrios Peschos, Elena Tsanou, Pavlos Dallas, Konstantinos Charalabopoulos, Christos Kanaris, Anna Batistatou

Published in: Diagnostic Pathology | Issue 1/2008

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Abstract

Introduction

Male breast cancer is rare compared to its female counterpart representing less than 1% of cancer in men. Moreover, mucinous carcinoma of the male breast is an extremely rare histological subtype of malignancy. Paget's disease of the nipple is rarely observed in males.

Case report

Herein, we describe a unique case of an 86 years old man with mucinous breast cancer presenting as Paget's disease of the nipple. According to the immunohistochemical evaluation the neoplastic cells were positive for estrogen (ER) and progesterone receptors (PR).

Conclusion

To our best knowledge this is the first case of mucinous male breast cancer presenting as Paget's disease of the nipple.
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Literature
1.
go back to reference Dhiab BT, Bouzid T, Gamoudi A, Hassouna JB, Khomsi F, Boussen H, Benna F, El May A, Hechiche M, Rahal K: Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999. Bull Cancer. 2005, 92: 281-285.PubMed Dhiab BT, Bouzid T, Gamoudi A, Hassouna JB, Khomsi F, Boussen H, Benna F, El May A, Hechiche M, Rahal K: Male breast cancer: about 123 cases collected at the Institute Salah-Azaiz of Tunis from 1979 to 1999. Bull Cancer. 2005, 92: 281-285.PubMed
2.
go back to reference Muir D, Kanthan R, Kanthan SC: Male versus female breast cancers. A population-based comparative immunohistochemical analysis. Arch Pathol Lab Med. 2003, 127: 36-41.PubMed Muir D, Kanthan R, Kanthan SC: Male versus female breast cancers. A population-based comparative immunohistochemical analysis. Arch Pathol Lab Med. 2003, 127: 36-41.PubMed
3.
go back to reference Weiss JR, Moysich KB, Swede H: Epidemiology of male breast cancer. Cancer Epidemiol Biomarkers Prev. 2005, 14: 20-26. 10.1158/1055-9965.EPI-05-0414.CrossRefPubMed Weiss JR, Moysich KB, Swede H: Epidemiology of male breast cancer. Cancer Epidemiol Biomarkers Prev. 2005, 14: 20-26. 10.1158/1055-9965.EPI-05-0414.CrossRefPubMed
4.
go back to reference Hayes R, Cummings B, Miller RA, Guha AK: Male Paget's disease of the breast. Cutan Med Surg. 2000, 4: 208-212. Hayes R, Cummings B, Miller RA, Guha AK: Male Paget's disease of the breast. Cutan Med Surg. 2000, 4: 208-212.
5.
go back to reference Kollmorgen DR, Varanasi JS, Edge SB, Carson WE: Paget's disease of the breast: a 33-year experience. J Am Coll Surg. 1998, 187: 171-177. 10.1016/S1072-7515(98)00143-4.CrossRefPubMed Kollmorgen DR, Varanasi JS, Edge SB, Carson WE: Paget's disease of the breast: a 33-year experience. J Am Coll Surg. 1998, 187: 171-177. 10.1016/S1072-7515(98)00143-4.CrossRefPubMed
6.
go back to reference Bodnar M, Miller OF, Tyler W: Paget's disease of the male breast associated with intraductal carcinoma. J Am Acad Dermatol. 1999, 40: 829-831.PubMed Bodnar M, Miller OF, Tyler W: Paget's disease of the male breast associated with intraductal carcinoma. J Am Acad Dermatol. 1999, 40: 829-831.PubMed
7.
go back to reference Gupta RK, Naran S, Lallu S, Fauck R: Needle aspiration cytodiagnosis of mucinous (colloid) carcinoma of male breast. Pathology. 2004, 35: 539-540. 10.1080/00313020310001619172.CrossRef Gupta RK, Naran S, Lallu S, Fauck R: Needle aspiration cytodiagnosis of mucinous (colloid) carcinoma of male breast. Pathology. 2004, 35: 539-540. 10.1080/00313020310001619172.CrossRef
8.
go back to reference Hodgson NC, Button JH, Franceschi D, Moffat FL, Livingstone AS: Male breast cancer: is the incidence increasing?. Ann Surg Oncol. 2004, 11: 751-755. 10.1245/ASO.2004.01.001.CrossRefPubMed Hodgson NC, Button JH, Franceschi D, Moffat FL, Livingstone AS: Male breast cancer: is the incidence increasing?. Ann Surg Oncol. 2004, 11: 751-755. 10.1245/ASO.2004.01.001.CrossRefPubMed
9.
go back to reference Nayak SK, Naik R, Upadhyaya K, Raghuveer CV, Pai MR: FNAC diagnosis of mucinous carcinoma of male breast – a case report. Indian J Pathol Microbiol. 2001, 44: 355-357.PubMed Nayak SK, Naik R, Upadhyaya K, Raghuveer CV, Pai MR: FNAC diagnosis of mucinous carcinoma of male breast – a case report. Indian J Pathol Microbiol. 2001, 44: 355-357.PubMed
10.
11.
go back to reference Buzdar AU: Breast cancer in men. Oncology (Williston Park). 2003, 17: 1361-1364. Buzdar AU: Breast cancer in men. Oncology (Williston Park). 2003, 17: 1361-1364.
12.
go back to reference Kidmas AT, Ugwu BT, Manasseh AN, Iya D, Opaluwa AS: Male breast malignancy in Jos university teaching hospital. West Afr J Med. 2005, 24: 36-40.PubMed Kidmas AT, Ugwu BT, Manasseh AN, Iya D, Opaluwa AS: Male breast malignancy in Jos university teaching hospital. West Afr J Med. 2005, 24: 36-40.PubMed
13.
go back to reference Olsson H: Estrogen receptor content in malignant breast tumors in men-a review. J Mammary Gland Biol Neoplasia. 2000, 5: 283-287. 10.1023/A:1009546811429.CrossRefPubMed Olsson H: Estrogen receptor content in malignant breast tumors in men-a review. J Mammary Gland Biol Neoplasia. 2000, 5: 283-287. 10.1023/A:1009546811429.CrossRefPubMed
14.
go back to reference Munoz de Toro MM, Maffini MV, Kass L, Luque EH: Proliferative activity and steroid hormone receptor status in male breast carcinoma. J Steroid Biochem Mol Biol. 1998, 67: 333-339. 10.1016/S0960-0760(98)00124-1.CrossRefPubMed Munoz de Toro MM, Maffini MV, Kass L, Luque EH: Proliferative activity and steroid hormone receptor status in male breast carcinoma. J Steroid Biochem Mol Biol. 1998, 67: 333-339. 10.1016/S0960-0760(98)00124-1.CrossRefPubMed
15.
go back to reference Rayson D, Erlichman C, Suman VJ, Roche PC, Wold LE, Ingle JN, Donohue JH: Molecular markers in male breast carcinoma. Cancer. 1998, 83: 1947-1955. 10.1002/(SICI)1097-0142(19981101)83:9<1947::AID-CNCR10>3.0.CO;2-J.CrossRefPubMed Rayson D, Erlichman C, Suman VJ, Roche PC, Wold LE, Ingle JN, Donohue JH: Molecular markers in male breast carcinoma. Cancer. 1998, 83: 1947-1955. 10.1002/(SICI)1097-0142(19981101)83:9<1947::AID-CNCR10>3.0.CO;2-J.CrossRefPubMed
16.
go back to reference Friedman MA, Hoffman PG, Dandolos EM, Dandolos EM, Lagios MD, Johnston WH, Siiteri PK: Estrogen receptors in male breast cancer: clinical and pathologic correlations. Cancer. 1981, 47: 134-137. 10.1002/1097-0142(19810101)47:1<134::AID-CNCR2820470122>3.0.CO;2-M.CrossRefPubMed Friedman MA, Hoffman PG, Dandolos EM, Dandolos EM, Lagios MD, Johnston WH, Siiteri PK: Estrogen receptors in male breast cancer: clinical and pathologic correlations. Cancer. 1981, 47: 134-137. 10.1002/1097-0142(19810101)47:1<134::AID-CNCR2820470122>3.0.CO;2-M.CrossRefPubMed
17.
go back to reference Nixon AJ, Neuberg D, Hayes DF, Gelman R, Connolly JL, Schnitt S, Abner A, Recht A, Vicini F, Harris JR: Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol. 1994, 12: 888-894.PubMed Nixon AJ, Neuberg D, Hayes DF, Gelman R, Connolly JL, Schnitt S, Abner A, Recht A, Vicini F, Harris JR: Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol. 1994, 12: 888-894.PubMed
18.
go back to reference Joshi MG, Lee AK, Loda M, Camus MG, Pedersen C, Heatley GJ, Hughes KS: Male breast carcinoma: an evaluation of prognostic factors contributing to a poorer outcome. Cancer. 1996, 177: 490-498. 10.1002/(SICI)1097-0142(19960201)77:3<490::AID-CNCR10>3.0.CO;2-#.CrossRef Joshi MG, Lee AK, Loda M, Camus MG, Pedersen C, Heatley GJ, Hughes KS: Male breast carcinoma: an evaluation of prognostic factors contributing to a poorer outcome. Cancer. 1996, 177: 490-498. 10.1002/(SICI)1097-0142(19960201)77:3<490::AID-CNCR10>3.0.CO;2-#.CrossRef
19.
go back to reference Kidwai N, Gong Y, Sun X, Deshpande CG, Yeldandi AV, Rao MS, Badve S: Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. Breast Cancer Res. 2004, 6: R18-R23. 10.1186/bcr733.PubMedCentralCrossRefPubMed Kidwai N, Gong Y, Sun X, Deshpande CG, Yeldandi AV, Rao MS, Badve S: Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. Breast Cancer Res. 2004, 6: R18-R23. 10.1186/bcr733.PubMedCentralCrossRefPubMed
20.
go back to reference Salvadori B, Saccozzi R, Manzari A, Andreola S, Conti RA, Cusumano F, Grassi M: Prognosis of breast cancer in males: an analysis of 170 cases. Eur J Cancer. 1994, 30: 930-935. 10.1016/0959-8049(94)90117-1.CrossRef Salvadori B, Saccozzi R, Manzari A, Andreola S, Conti RA, Cusumano F, Grassi M: Prognosis of breast cancer in males: an analysis of 170 cases. Eur J Cancer. 1994, 30: 930-935. 10.1016/0959-8049(94)90117-1.CrossRef
21.
go back to reference Aghadiuno PU: Cancer of the male breast: analysis of forty-three cases in Ibadan, Nigeria. Afr J Med Med Sci. 1987, 16 (1): 15-26.PubMed Aghadiuno PU: Cancer of the male breast: analysis of forty-three cases in Ibadan, Nigeria. Afr J Med Med Sci. 1987, 16 (1): 15-26.PubMed
22.
go back to reference Borgen PI, Senie RT, McKinnon WM, Rosen PP: Carcinoma of the male breast: analysis of prognosis compared with matched female patients. Ann Surg Oncol. 1997, 4: 385-388. 10.1007/BF02305550.CrossRefPubMed Borgen PI, Senie RT, McKinnon WM, Rosen PP: Carcinoma of the male breast: analysis of prognosis compared with matched female patients. Ann Surg Oncol. 1997, 4: 385-388. 10.1007/BF02305550.CrossRefPubMed
23.
go back to reference Cutuli B, Lacroze M, Dilhuydy JM, Velten M, De Lafontan B, Marchal C, Resbeut M, Graic Y, Campana F, Moncho-Bernier V: Male breast cancer: results of the treatments and prognostic factors in 397 cases. Eur J Cancer. 1995, 31: 1960-1964. 10.1016/0959-8049(95)00366-5.CrossRef Cutuli B, Lacroze M, Dilhuydy JM, Velten M, De Lafontan B, Marchal C, Resbeut M, Graic Y, Campana F, Moncho-Bernier V: Male breast cancer: results of the treatments and prognostic factors in 397 cases. Eur J Cancer. 1995, 31: 1960-1964. 10.1016/0959-8049(95)00366-5.CrossRef
24.
go back to reference Gadenne C, Contesso G, Travagli JP, Rouesse J, Fontaine F: Male breast tumours. Anatomico-clinical study based on 73 cases (author's transl). Nouv Presse Med. 1982, 11 (31): 2331-2334.PubMed Gadenne C, Contesso G, Travagli JP, Rouesse J, Fontaine F: Male breast tumours. Anatomico-clinical study based on 73 cases (author's transl). Nouv Presse Med. 1982, 11 (31): 2331-2334.PubMed
25.
go back to reference Bergs EA, Tanis PJ, Steller EP: Three men with breast cancer. Ned Tijdschr Geneeskd. 2005, 149: 534-537.PubMed Bergs EA, Tanis PJ, Steller EP: Three men with breast cancer. Ned Tijdschr Geneeskd. 2005, 149: 534-537.PubMed
26.
go back to reference Barlund M, Kuukasjarvi T, Syrjakoski K, Auvinen A, Kallioniemi A: Frequent amplification and overexpression of CCND1 in male breast cancer. Int J Cancer. 2004, 111: 968-971. 10.1002/ijc.20307.CrossRefPubMed Barlund M, Kuukasjarvi T, Syrjakoski K, Auvinen A, Kallioniemi A: Frequent amplification and overexpression of CCND1 in male breast cancer. Int J Cancer. 2004, 111: 968-971. 10.1002/ijc.20307.CrossRefPubMed
27.
go back to reference Petroni S, Mangia A, D'Amico C, Simone G: Expression of steroid receptors and DNA synthesis in male breast cancer. Pathologica. 2003, 95: 31-36.PubMed Petroni S, Mangia A, D'Amico C, Simone G: Expression of steroid receptors and DNA synthesis in male breast cancer. Pathologica. 2003, 95: 31-36.PubMed
Metadata
Title
Mucinous breast carcinoma presenting as Paget's disease of the nipple in a man: A case report
Authors
Dimitrios Peschos
Elena Tsanou
Pavlos Dallas
Konstantinos Charalabopoulos
Christos Kanaris
Anna Batistatou
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2008
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-3-42

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