Published in:
Open Access 01-12-2008 | Case Report
Sickle cell nephropathy with diffuse proliferative lupus nephritis: a case report
Published in: Diagnostic Pathology | Issue 1/2008
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Background
Sickle cell nephropathy (SCN) is an important cause of mortality in patients with sickle cell disease. SCA with systemic lupus erythematosus (SLE) is known in children and less common in adults, however diffuse proliferative lupus nephritis (DPLN) with SCN has rarely been reported in adults. It requires early diagnosis and aggressive management.
Case presentation
We present here a 35 years old lady with sickle cell disease who presented with edema, dyspnoea on exertion, pyuria and had raised s. creatinine of 7 mg%. Her biopsy revealed SCN with DPLN. She is on maintenance hemodialysis after 2 months of diagnosis.
Conclusion
DPLN with SCN is a rare entity with poor prognosis, which may be overlooked and needs aggressive management.