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Breast Cancer Research and Treatment
Published in: Breast Cancer Research and Treatment 3/2010

01-10-2010 | Letter to the Editor

Mouse mammary tumor-like virus and human breast cancer

Authors: Wendy K. Glenn, Brian Salmons, James S. Lawson, Noel J. Whitaker

Published in: Breast Cancer Research and Treatment | Issue 3/2010

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Excerpt

Park et al. from Melbourne, Australia, report their failure to identify by standard polymerase chain reaction (PCR) techniques, mouse mammary tumor virus (MMTV)-like env sequences in DNA extracted from 42 formalin-fixed invasive breast cancer specimens, all from women living in Melbourne [1]. This negative outcome is in stark contrast to the many reports of the positive identification of MMTV-like env sequences in breast cancers from independent laboratories in Australia, Argentina, China, Italy, Mexico, Tunisia, and the United States [2]. However, in past years other workers have also failed to identify these sequences in breast cancers [3‐5]. …
Literature
1.
Park DJ, Southey MC, Giles GG, Hopper JL (2010) No evidence of MMTV-like env sequences in specimens from the Australian Breast Cancer Family Study. Breast Cancer Res Treat. doi: 10.​1007/​s10549-010-0946-4
2.
Lawson JS, Glenn WK, Salmons B, Ye Y, Heng B, Moody P, Johal H, Rawlinson WD, Delprado W, Lutze-Mann L, Whitaker NJ (2010) Mouse mammary tumor virus-like sequences in human breast cancer. Cancer Res 70:3576–3585CrossRefPubMed
3.
Zangen R, Harden S, Cohen D, Parrella P, Sidransky D (2002) Mouse mammary tumor-like env gene as a molecular marker for breast cancer? Int J Cancer 102:304–307CrossRefPubMed
4.
Witt A, Hartmann B, Marton E, Zeillinger R, Schreiber M, Kubista E (2003) The mouse mammary tumor virus-like env gene sequence is not detectable in breast cancer tissue of Austrian patients. Oncol Rep 10:1025–1029PubMed
5.
Mant C, Cason J (2004) A human murine mammary tumour virus-like agent is an unconvincing aetiological agent for human breast cancer. Rev Med Virol 14:169–177CrossRefPubMed
6.
Wang Y, Holland JF, Bleiweiss IJ, Melana S, Liu X, Pelisson L, Cantarella A, Stellrecht K, Mani S, Pogo BG-T (1995) Detection of mammary tumor virus env gene-like sequences in human breast cancer. Cancer Res 55:5173–5179PubMed
7.
Ford CE, Faedo M, Rawlinson WD (2004) MMTV virus-like RNA transcripts and DNA are found in affected cells of human breast cancer. Clin Cancer Res 10:7284–7289CrossRefPubMed
8.
Lawson JS, Heng B (2010) Viruses and breast cancer. Review. Cancers 2:752–772CrossRef
9.
Mant C, Gillett C, D’Arrigo C, Cason J (2004) Human murine mammary tumour virus-like agents are genetically distinct from endogenous retroviruses and are not detectable in breast cancer cell lines or biopsies. Virology 318:393–404CrossRefPubMed
10.
Bindra A, Muradrasoli S, Kisekka R, Nordgren H, Warnberg F, Blomberg J (2007) Search for DNA of exogenous mouse mammary tumor virus-related virus in human breast cancer samples. J Gen Virol 88:1806–1809CrossRefPubMed
11.
Fukuoka H, Moriuchi M, Yano H, Nagayasu T, Moriuchi H (2008) No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer. J Med Virol 80:1447–1451CrossRefPubMed
Metadata
Title
Mouse mammary tumor-like virus and human breast cancer
Authors
Wendy K. Glenn
Brian Salmons
James S. Lawson
Noel J. Whitaker
Publication date
01-10-2010
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 3/2010
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-010-1021-x

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