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Cancer Microenvironment
Published in: Cancer Microenvironment 2/2013

01-08-2013 | Original Article

Monocytes and Macrophages in Cancer: Development and Functions

Authors: David M. Richards, Jan Hettinger, Markus Feuerer

Published in: Cancer Microenvironment | Issue 2/2013

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Abstract

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell-derived macrophages. After their recruitment into the tumor tissue, they can differentiate into tumor-associated macrophages, a very heterogeneous cell population in terms of phenotype and pro-tumor function, supporting tumor initiation, local progression and distant metastasis. Therefore, targeting monocytes and macrophages is a promising immunotherapeutic approach. This review will focus on the development of monocytes as macrophage precursors, the functions of tumor-associated macrophages and the possibility of interfering with tumor development and progression by targeting these myeloid cells.
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Metadata
Title
Monocytes and Macrophages in Cancer: Development and Functions
Authors
David M. Richards
Jan Hettinger
Markus Feuerer
Publication date
01-08-2013
Publisher
Springer Netherlands
Published in
Cancer Microenvironment / Issue 2/2013
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI
https://doi.org/10.1007/s12307-012-0123-x

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