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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

Monocyte subset recruitment to the peritoneum following abdominal surgical incision in mice

Authors: N Bunker, KP O'Dea, JM Handy, M Takata

Published in: Critical Care | Special Issue 1/2011

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Excerpt

The current gold standard animal model for sepsis is CLP [1]; however, this model does not allow segregation of the immune responses to infection from those due to surgical incision/trauma. We hypothesised that surgical incision of the peritoneal wall in mice would be a potent stimulus for the recruitment of monocytes, particularlythe inflammatory Gr-1Hi subset [2], to the peritoneal space where they would be capable of mounting a proinflammatory response to subsequent septic challenges. …
Literature
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Metadata
Title
Monocyte subset recruitment to the peritoneum following abdominal surgical incision in mice
Authors
N Bunker
KP O'Dea
JM Handy
M Takata
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9666

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