Published in:
01-09-2017 | Review Article
Molecular Pathogenesis of Liver Cancer
Authors:
Mehmet Ozturk, Tugce Batur, Umut Ekin, Aybike Erdogan, Evin İscan, Umur Keles, Ozden Oz, Cigdem Ozen
Published in:
Journal of Gastrointestinal Cancer
|
Issue 3/2017
Login to get access
Excerpt
Most frequent primary liver cancers are hepatocellular carcinoma (HCC) and cholangiocarcinoma in adults, and hepatoblastoma in children. More than 80% of liver tumors are HCCs [
1]. This short review will focus primarily on the molecular pathogenesis of HCC; readers are referred to our previous reviews for a more comprehensive analysis [
2,
3]. Worldwide, each year, more than 740,000 people die of HCC [
4]. The most efficient treatment for HCC is liver transplantation provided that it is detected early enough. Surgical removal and chemo-embolization of tumor nodules are other alternatives. These tumors are usually resistant to chemo- or radiotherapy [
1]. Only one drug, namely sorafenib, is approved for targeted therapy of HCC, but its efficacy is very limited [
5]. …
