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Open Access 01-01-2018 | Original Article

Molecular imaging in musculoskeletal infections with ^99mTc-UBI 29-41 SPECT/CT

Authors: Mike Sathekge, Osvaldo Garcia-Perez, Diana Paez, Noura El-Haj, Taylor Kain-Godoy, Ismaheel Lawal, Enrique Estrada-Lobato

Published in: Annals of Nuclear Medicine | Issue 1/2018

Abstract

Objective

To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal infection using ^99mTc-UBI 29-4.

Materials and methods

184 patients with suspected musculoskeletal infection who underwent planar and SPECT/CT imaging with ^99mTc-UBI 29-41 were included. Planar, SPECT-only and SPECT/CT images were reviewed by two independent analysts for presence of bone or soft tissue infection. Final diagnosis was confirmed with tissue cultures, surgery/histology or clinical follow-up.

Results

^99mTc-UBI 29-41 was true positive in 105/184 patients and true negative in 65/184 patients. When differentiating between soft tissue and bone infection, planar + SPECT-only imaging had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 95.0, 74.3, 84.8, 91.3 and 86.9%, respectively, versus 99.0, 94.5, 92.5, 98.5 and 94.5% for SPECT/CT. SPECT/CT resulted in a change in reviewers’ confidence in the final diagnosis in 91/184 patients. Inter-observer agreement was better with SPECT/CT compared with planar + SPECT imaging (kappa 0.87, 95% CI 0.71–0.85 versus kappa 0.81, 95% CI 0.58–0.75).

Conclusion

Addition of CT to planar and SPECT-only imaging led to an increase in diagnostic performance and an improvement in reviewers’ confidence and inter-observer agreement in differentiating bone from soft tissue infection.

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Title: Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT
Authors: Mike Sathekge
Osvaldo Garcia-Perez
Diana Paez
Noura El-Haj
Taylor Kain-Godoy
Ismaheel Lawal
Enrique Estrada-Lobato
Publication date: 01-01-2018
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 1/2018
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-017-1219-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Molecular imaging in musculoskeletal infections with ^99mTc-UBI 29-41 SPECT/CT

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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