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Archives of Virology
Published in: Archives of Virology 2/2019

01-02-2019 | Brief Report

Molecular evolutionary and antigenic characteristics of newly isolated H9N2 avian influenza viruses in Guangdong province, China

Authors: Jipei Zhang, Huiji Wu, Yishan Zhang, Mengrui Cao, Morgan Brisse, Wanjun Zhu, Rongxu Li, Minfang Liu, Mingsheng Cai, Jianhong Chen, Jidang Chen

Published in: Archives of Virology | Issue 2/2019

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Abstract

Four new H9N2 avian influenza viruses (AIVs) were isolated from domestic birds in Guangdong between December 2015 and April 2016. Nucleotide sequence comparisons indicated that most of the internal genes of these four strains were highly similar to those of human H7N9 viruses. Amino acid substitutions and deletions found in the HA and NA proteins indicated that all four of these new isolates may have an enhanced ability to infect humans and other mammals. A cross-hemagglutinin-inhibition assay, conducted with two vaccine strains that are broadly used in China, suggested that antisera against vaccine candidates could not provide complete inhibition of the new isolates.
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Metadata
Title
Molecular evolutionary and antigenic characteristics of newly isolated H9N2 avian influenza viruses in Guangdong province, China
Authors
Jipei Zhang
Huiji Wu
Yishan Zhang
Mengrui Cao
Morgan Brisse
Wanjun Zhu
Rongxu Li
Minfang Liu
Mingsheng Cai
Jianhong Chen
Jidang Chen
Publication date
01-02-2019
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 2/2019
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-018-4103-4

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