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01-01-2016 | Review Article

Molecular and anatomical evidence for the input pathway- and target cell type-dependent regulation of glutamatergic synapses

Author: Miwako Yamasaki

Published in: Anatomical Science International | Issue 1/2016

Abstract

Glutamate mediates most fast excitatory transmission in the central nervous system by activating primarily two types of ionotropic glutamate receptors: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptors. Differential subunit combinations generate great functional diversity in both categories of receptors, making them highly suitable for meeting complex functional requirements. Converging evidence has indicated that distinct AMPA and NMDA receptor subtypes are selectively targeted to functionally different synapses according to different factors, including presynaptic inputs, postsynaptic cell types, and synaptic configurations. This article provides an overview of recent progress in understanding the basic principles governing the synaptic allocation of AMPA and NMDA receptors, and discusses the underlying mechanisms and functional implications.

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Title: Molecular and anatomical evidence for the input pathway- and target cell type-dependent regulation of glutamatergic synapses
Author: Miwako Yamasaki
Publication date: 01-01-2016
Publisher: Springer Japan
Published in: Anatomical Science International / Issue 1/2016
Print ISSN: 1447-6959
Electronic ISSN: 1447-073X
DOI: https://doi.org/10.1007/s12565-015-0303-0

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Molecular and anatomical evidence for the input pathway- and target cell type-dependent regulation of glutamatergic synapses

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