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European Journal of Nutrition

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01-10-2012 | Original Contribution

Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content

Authors: Stephan W. Barth, Tatiana C. L. Koch, Bernhard Watzl, Helmut Dietrich, Frank Will, Achim Bub

Published in: European Journal of Nutrition | Issue 7/2012

Abstract

Purpose

The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men.

Methods

In this controlled, randomized, and parallel study, n = 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m² received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined.

Results

CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: −1.0 ± 1.3 vs. CB: −0.2 ± 0.9, p < 0.05). The IL-6-174 G/C polymorphism showed an interaction with body fat reduction induced by CloA. Solely in C/C, but not in G/C or G/G variants, a significant reduction in body fat after 4 weeks of CloA intervention was detectable.

Conclusion

The observed diet–gene interaction might be a first indication for the impact of individual genetic background on CloA-mediated bioactivity on obesity-associated comorbidities.

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Title: Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content
Authors: Stephan W. Barth
Tatiana C. L. Koch
Bernhard Watzl
Helmut Dietrich
Frank Will
Achim Bub
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: European Journal of Nutrition / Issue 7/2012
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-011-0264-6

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