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Journal of Cardiothoracic Surgery

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Open Access 01-12-2023 | Mitral Valve Replacement | Case Report

Prosthetic valve endocarditis secondary to Tropheryma whipplei in a patient with chronic polyarthritis

Authors: Mauricio J. Kahn, David M. Ennis, Dennis G. Delgado

Published in: Journal of Cardiothoracic Surgery | Issue 1/2023

Abstract

Background

Whipple’s disease is a chronic multisystemic infectious disease that rarely presents as culture-negative endocarditis. Most patients reported with Tropheryma whipplei endocarditis involve a native valve and few describe prosthetic valve disease.

Case presentation

A patient with chronic polyarthritis and previous mitral valve replacement developed decompensated heart failure without fever. Transesophageal echocardiography revealed a prosthetic mitral valve vegetation and he underwent prosthetic mitral valve replacement. Blood and prosthetic mitral valve cultures were unrevealing. Broad-range polymerase chain reaction (PCR) of the extracted valve and subsequent Periodic-acid-Schiff (PAS) staining established the diagnosis of T. whipplei prosthetic valve endocarditis.

Conclusion

Whipple’s disease may present as culture-negative infective endocarditis and affect prosthetic valves. Histopathology with PAS staining and broad-range PCR of excised valves are essential for the diagnosis. Greater clinical awareness and implementation of these diagnostic procedures should result in an increased reported incidence of this rare disease.

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Title: Prosthetic valve endocarditis secondary to Tropheryma whipplei in a patient with chronic polyarthritis
Authors: Mauricio J. Kahn
David M. Ennis
Dennis G. Delgado
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Mitral Valve Replacement
Tropheryma Whipplei
Whipple's Disease
Heart Failure
Endocarditis
Mitral Valve Replacement
Mitral Valve Replacement
Rheumatoid Arthritis
Polymerase Chain Reaction
Published in: Journal of Cardiothoracic Surgery / Issue 1/2023
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-023-02287-1

2024 ASCO Annual Meeting

Springer Medicine

Prosthetic valve endocarditis secondary to Tropheryma whipplei in a patient with chronic polyarthritis

Abstract

Background

Case presentation

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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