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Journal of Cardiothoracic Surgery

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Open Access 01-12-2021 | Mitral Valve Replacement | Research article

New stent for transapical mitral valve replacement in acute swine experiment

Authors: Yu Zou, Peng Teng, Liang Ma

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

Many patients with mitral regurgitation are denied open-heart surgery due to perceived high risk. Transcatheter mitral valve replacement is a therapeutic alternative for patients at high surgical risk. This study aimed to assess the feasibility of a new self-expanding valved stent for transcatheter mitral valve replacement via apex in an acute animal model.

Methods

Eight porcine experiments were performed in the acute study. A left thoracotomy was performed, and the new self-expanding transcatheter valved stent was deployed under fluoroscopic guidance in the native mitral annulus via apex. Hemodynamic data were recorded before and after implantation. Mitral annulus diameter and valve area were measured using echocardiography. Transvalvular and left ventricular outflow tract pressure gradients were measured using invasive methods.

Results

Seven animals underwent successful transapical mitral valve replacement; the implantation was unsuccessful in one animal. The mean procedure time, defined from placement to tightening of the purse-string suture, was 17.14 ± 7.86 min. Hemodynamic data before and after transapical mitral valve replacement showed no difference in statistical analysis. The mean diameter of the self-expanding device after implantation was 2.58 ± 1.04 cm; the mean functional area was 2.70 ± 0.26 cm². Trace-to-mild central and paravalvular leaks were detected in 7 valves. The mean pressure gradient across the self-expanding device was 2.00 ± 0.82 mmHg; the corresponding gradient across the LVOT was 3.28 ± 1.11 mmHg. Postmortem evaluation confirmed precise device positioning in 7 animals with no signs of LVOT obstruction.

Conclusion

Transcatheter mitral replacement of the new valved stent was confirmed feasible in acute preclinical models. The new stent reveals optimal design parameters.

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Title: New stent for transapical mitral valve replacement in acute swine experiment
Authors: Yu Zou
Peng Teng
Liang Ma
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Mitral Valve Replacement
Mitral Valve Replacement
Transcatheter Mitral Valve Replacement
Mitral Valve Replacement
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01483-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

New stent for transapical mitral valve replacement in acute swine experiment

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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