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Cancer Cell International
Published in: Cancer Cell International 1/2021

Open Access 01-12-2021 | Review

Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics

Authors: Yanjie Guan, Yifei Wang, Bo Li, Kai Shen, Quanfu Li, Yingyin Ni, Lei Huang

Published in: Cancer Cell International | Issue 1/2021

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Abstract

The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. In this review, we describe the regulatory mechanisms of mitophagy in mammals and yeasts and highlight the recent advances relevant to its function in carcinogenesis and drug resistance. Finally, a section has been dedicated to describing the role of mitophagy in anticancer therapeutics, which is a new frontier that offers a precise and promising strategy.
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Metadata
Title
Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
Authors
Yanjie Guan
Yifei Wang
Bo Li
Kai Shen
Quanfu Li
Yingyin Ni
Lei Huang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2021
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-021-02065-w

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