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European Journal of Nutrition
Published in: European Journal of Nutrition 3/2013

01-04-2013 | Original Contribution

Milk phospholipid and plant sterol-dependent modulation of plasma lipids in healthy volunteers

Authors: Sylvia Keller, Angelika Malarski, Carolin Reuther, Romy Kertscher, Michael Kiehntopf, Gerhard Jahreis

Published in: European Journal of Nutrition | Issue 3/2013

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Abstract

Purpose

Hypolipidemic and/or hypocholesterolemic effects are presumed for dietary milk phospholipid (PL) as well as plant sterol (PSt) supplementation. The aim was to induce changes in plasma lipid profile by giving different doses of milk PL and a combination of milk PL with PSt to healthy volunteers.

Methods

In an open-label intervention study, 14 women received dairy products enriched with moderate (3 g PL/day) or high (6 g PL/day) dose of milk PL or a high dose of milk PL combined with PSt (6 g PL/day + 2 g PSt/day) during 3 periods each lasting 10 days.

Results

Total cholesterol concentration and HDL cholesterol concentration were reduced following supplementation with 3 g PL/day. No significant change in LDL cholesterol concentration was found compared with baseline. High PL dose resulted in an increase of LDL cholesterol and unchanged HDL cholesterol compared with moderate PL dose. The LDL/HDL ratio and triglyceride concentration remained constant within the study. Except for increased phosphatidyl ethanolamine concentrations, plasma PL concentrations were not altered during exclusive PL supplementations. A combined high-dose PL and PSt supplementation led to decreased plasma LDL cholesterol concentration, decreased PL excretion, increased plasma sphingomyelin/phosphatidyl choline ratio, and significant changes in plasma fatty acid distribution compared with exclusive high-dose PL supplementation.

Conclusion

Milk PL supplementations influence plasma cholesterol concentrations, but without changes of LDL/HDL ratio. A combined high-dose milk PL and PSt supplementation decreases plasma LDL cholesterol concentration, but it probably enforces absorption of fatty acids or fatty acid-containing hydrolysis products that originated during lipid digestion.
Appendix
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Metadata
Title
Milk phospholipid and plant sterol-dependent modulation of plasma lipids in healthy volunteers
Authors
Sylvia Keller
Angelika Malarski
Carolin Reuther
Romy Kertscher
Michael Kiehntopf
Gerhard Jahreis
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Journal of Nutrition / Issue 3/2013
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0427-0

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