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Endocrine
Published in: Endocrine 2/2018

01-11-2018 | Side Effects of Endocrine Treatments

Mild leukopenia following denosumab treatment in a woman with postmenopausal osteoporosis

Authors: Stergios A. Polyzos, Evangelos Terpos

Published in: Endocrine | Issue 2/2018

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Excerpt

Denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor kappaB ligand (RANKL), is considered an efficient and safe treatment of postmenopausal osteoporosis [1]. Its main adverse effects, including osteonecrosis of the jaw, atypical femoral fractures, and vertebral fractures occurring upon its discontinuation, are rare, thus the benefit from the reduction of osteoporotic fractures overcomes the risks [2]. …
Literature
1.
A.D. Anastasilakis, K.A. Toulis, S.A. Polyzos, C.D. Anastasilakis, P. Makras, Long-term treatment of osteoporosis: safety and efficacy appraisal of denosumab. Ther. Clin. Risk Manag. 8, 295–306 (2012)CrossRef
2.
A.D. Anastasilakis, S.A. Polyzos, P. Makras, Therapy of endocrine disease: Denosumab vs bisphosphonates for the treatment of postmenopausal osteoporosis. Eur. J. Endocrinol. 179, R31–r45 (2018)CrossRef
3.
G.S. Breuer, M. Ehrenfeld, I. Rosner, A. Balbir-Gurman, D. Zisman, S. Oren, D. Paran, Late-onset neutropenia following rituximab treatment for rheumatologic conditions. Clin. Rheumatol. 33, 1337–1340 (2014)CrossRef
Metadata
Title
Mild leukopenia following denosumab treatment in a woman with postmenopausal osteoporosis
Authors
Stergios A. Polyzos
Evangelos Terpos
Publication date
01-11-2018
Publisher
Springer US
Published in
Endocrine / Issue 2/2018
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-018-1699-9

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