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Neurology and Therapy
Published in: Neurology and Therapy 4/2023

Open Access 15-05-2023 | Migraine | ORIGINAL RESEARCH

Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study

Authors: Zhen-Ni Zhao, Zi-Qian Zhang, Qian-Qian Wang, Bao-Ling Zhao, He Wang, Xue-Jun Ge, Fei-Yan Yu

Published in: Neurology and Therapy | Issue 4/2023

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Abstract

Introduction

Previous observational studies have associated periodontitis (PD) with migraine; however, the results are inconclusive and the causality of the association between PD and migraine remains unclear. This two-sample Mendelian randomization (MR) study was performed to explore the bi-directional causal relationship between PD and migraine.

Methods

To investigate the relationship between PD (17,353 cases; 28,210 controls) and migraine (1072 cases; 360,122 controls), we used genetic tools from the largest available genome-wide association study of European descent. Inverse variance-weighted (IVW) and a series of sensitivity analyses were used to explore the association between migraine and PD. We performed an MR study using seven SNPs (single nucleotide polymorphisms) as instrumental variables for PD to investigate the causal relationship between migraine and PD.

Results

We found no significant causal relationship between PD and migraine (odds ratio, OR = 1.000; 95% confidence interval, CI = 0.99–1.00; p = 0.65). Similarly, no evidence supported a causal relationship between migraine and PD (OR = 0.07; CI = 2.04 × 10–9–2.65 × 106; p = 0.77). A sensitivity analysis revealed that no potential polymorphic effect (p = 0.356) and heterogeneity (p = 0.652) exists for the variants used in constructing the genetic instrument.

Conclusions

Based on the results of our MR study, there is no causal relationship between PD and migraines or migraines and PD.
Appendix
Available only for authorised users
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Metadata
Title
Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study
Authors
Zhen-Ni Zhao
Zi-Qian Zhang
Qian-Qian Wang
Bao-Ling Zhao
He Wang
Xue-Jun Ge
Fei-Yan Yu
Publication date
15-05-2023
Publisher
Springer Healthcare
Keyword
Migraine
Published in
Neurology and Therapy / Issue 4/2023
Print ISSN: 2193-8253
Electronic ISSN: 2193-6536
DOI
https://doi.org/10.1007/s40120-023-00484-7

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