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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2023

Open Access 01-12-2023 | Migraine | Review

Genetics of migraine: where are we now?

Authors: Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska-Prosół, Dilara Onan, Karol Marschollek, Wietse Wiels, Petr Mikulenka, Fatemeh Farham, Cédric Gollion, Anne Ducros, on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)

Published in: The Journal of Headache and Pain | Issue 1/2023

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Abstract

Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small increase in overall migraine risk. The more than 180 known variants belong to several complex networks of “pro-migraine” molecular abnormalities, which are mainly neuronal or vascular. Genetics has also highlighted the importance of shared genetic factors between migraine and its major co-morbidities, including depression and high blood pressure. Further studies are still needed to map all of the susceptibility loci for migraine and then to understand how these genomic variants lead to migraine cell phenotypes.
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Metadata
Title
Genetics of migraine: where are we now?
Authors
Lou Grangeon
Kristin Sophie Lange
Marta Waliszewska-Prosół
Dilara Onan
Karol Marschollek
Wietse Wiels
Petr Mikulenka
Fatemeh Farham
Cédric Gollion
Anne Ducros
on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)
Publication date
01-12-2023
Publisher
Springer Milan
Keywords
Migraine
Aura
Published in
The Journal of Headache and Pain / Issue 1/2023
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-023-01547-8

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