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The Journal of Headache and Pain

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Open Access 01-12-2022 | Migraine | Research

Cerebral blood flow alterations in migraine patients with and without aura: An arterial spin labeling study

Authors: Tong Fu, Lindong Liu, Xiaobin Huang, Di Zhang, Yujia Gao, Xindao Yin, Hai Lin, Yongming Dai, Xinying Wu

Published in: The Journal of Headache and Pain | Issue 1/2022

Abstract

Background

Migraine aura is a transient, fully reversible visual, sensory, or other central nervous system symptom that classically precedes migraine headache. This study aimed to investigate cerebral blood flow (CBF) alterations of migraine with aura patients (MwA) and without aura patients (MwoA) during inter-ictal periods, using arterial spin labeling (ASL).

Methods

We evaluated 88 migraine patients (32 MwA) and 44 healthy control subjects (HC) who underwent a three-dimensional pseudo-continuous ASL MRI scanning. Voxel-based comparison of normalized CBF was conducted between MwA and MwoA. The relationship between CBF variation and clinical scale assessment was further analyzed. The mean CBF values in brain regions showed significant differences were calculated and considered as imaging features. Based on these features, different machine learning–based models were established to differentiate MwA and MwoA under five-fold cross validation. The predictive ability of the optimal model was further tested in an independent sample of 30 migraine patients (10 MwA).

Results

In comparison to MwoA and HC, MwA exhibited higher CBF levels in the bilateral superior frontal gyrus, bilateral postcentral gyrus and cerebellum, and lower CBF levels in the bilateral middle frontal gyrus, thalamus and medioventral occipital cortex (all p values < 0.05). These variations were also significantly correlated with multiple clinical rating scales about headache severity, quality of life and emotion. On basis of these CBF features, the accuracies and areas under curve of the final model in the training and testing samples were 84.3% and 0.872, 83.3% and 0.860 in discriminating patients with and without aura, respectively.

Conclusion

In this study, CBF abnormalities of MwA were identified in multiple brain regions, which might help better understand migraine-stroke connection mechanisms and may guide patient-specific decision-making.

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Title: Cerebral blood flow alterations in migraine patients with and without aura: An arterial spin labeling study
Authors: Tong Fu
Lindong Liu
Xiaobin Huang
Di Zhang
Yujia Gao
Xindao Yin
Hai Lin
Yongming Dai
Xinying Wu
Publication date: 01-12-2022
Publisher: Springer Milan
Keywords: Migraine
Aura
Headache
Published in: The Journal of Headache and Pain / Issue 1/2022
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-022-01501-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cerebral blood flow alterations in migraine patients with and without aura: An arterial spin labeling study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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