Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2021

Open Access 01-12-2021 | Migraine | Research

A volumetric magnetic resonance imaging study in migraine

Authors: Laila Elmously Naguib, Ghada Saed Abdel Azim, Mohammed Abdelrazek Abdellatif

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Login to get access

Abstract

Background

Although migraine phenotype has been widely described, the explanation of migraine pathophysiology still has a gap that might be partly bridged by neuroimaging investigations. The aim of the study is to assess volumetric brain changes in migraineurs compared with controls, and in episodic migraine in comparison to chronic type. Structural brain changes in migraineurs (with and without aura) were assessed by an automated segmentation method (Free Surfer). T1-weighted MRIs of 25 migraineurs (14 diagnosed as episodic type and 11 diagnosed as chronic migraine) and 25 headache-free controls were evaluated and processed.

Results

Migraine patients had significant reduction of the volume of total brain, grey matter, brain stem, cerebellum, basal ganglia, thalamus, hippocampus and amygdala in comparison to control subjects. Patients with chronic migraine had significant reduction in volume of total brain, grey matter, cerebellum and frontal lobe thickness in comparison to those with episodic migraine.

Conclusion

Migraineurs showed volumetric brain changes mainly in areas related to central processing of pain and in areas specific for migraine (such as brain stem) when compared to healthy controls. Chronic migraineurs showed significant reduction in grey matter, in areas involved in processing of pain, cognition and multisensory integration versus patients with episodic migraine, which adds insight into the pathophysiology of migraine as a progressive disorder that may have long-term impacts on the brain as regards structure and function.
Literature
1.
Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: a systematic review and meta-analysis. Neurology. 2013;81(14):1260–8. PubMedPubMedCentralCrossRef
2.
3.
Jin C, Yuan K, Zhao L, Zhao L, Yu D, von Deneen KM, et al. Structural and functional abnormalities in migraine patients without aura. NMR Biomed. 2013;26(1):58–64.PubMedCrossRef
4.
Bigal ME, Lipton RB. What predicts the change from episodic to chronic migraine? Curr Opin Neurol. 2009;22:269–76.PubMedCrossRef
5.
Mathew NT. Pathophysiology of chronic migraine and mode of action of preventive medications. Headache. 2011;51(Suppl 2):84–92.PubMedCrossRef
6.
Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders (beta version). Cephalalgia. 2013;33(9):629–808.CrossRef
7.
Bagley L, Rendas-Baum R, Gregory A, Yang M, Varon S, Lee J, et al. Validating migraine specific quality of life questionnaire. Headache. 2012;52(3):409–21.CrossRefPubMed
8.
Beck T, Steer A, Brown K. Manual for the beck depression inventory–II. San Antonio: Psychological Corporation; 1996.
9.
Mansbach W, Mac Dougall E, Rosenzweig S. The Brief Cognitive Assessment Tool (BCAT): a new test emphasizing contextual memory, executive functions, attentional capacity, and the prediction of instrumental activities of daily living. J Clin Exp Neuropsychol. 2012;34(2):183–94.PubMedCrossRef
10.
Reuter M, Rosas D, Fischl B. Highly accurate inverse consistent registration: a robust approach. Neuroimage. 2010;53(4):1181–96.PubMedCrossRef
11.
Segonne F, Dale M, Busa E, Glessner M, Salat D, Hahn K, et al. A hybrid approach to the skull stripping problem in MRI. Neuroimage. 2004;22:1060–75.PubMedCrossRef
12.
Fischl B, Salat D, Busa E, Albert M, Dieterich M, Haselgrove C, et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33:341–55.PubMedCrossRef
13.
Fischl B, Salat D, van der Kouwe A, Makris N, Ségonne F, Quinn T, et al. Sequence-independent segmentation of magnetic resonance images. Neuroimage. 2004;23(1):S69-84.PubMedCrossRef
14.
Sled J, Zijdenbos P, Evans C. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging. 1998;17:87–97.PubMedCrossRef
15.
Fischl B, Liu A, Dale M. Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging. 2001;20:70–80.PubMedCrossRef
16.
Segonne F, Pacheco J, Fischl B. Geometrically accurate topology-correction of cortical surfaces using nonseparating loops. IEEE Trans Med Imaging. 2007;26:518529.CrossRef
17.
Dale M, Fischl B, Sereno I. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 1999;9:179–94.PubMedCrossRef
18.
Dale M, Sereno I. Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: a linear approach. J Cogn Neurosci. 1993;5:162–76.PubMedCrossRef
19.
20.
Gudmundsson S, Scher I, Sigurdsson S, Mirjam G, JeanSebastien V, Gudny E. Migraine, depression, and brain volume. The AGES-Reykjavik Study. Neurology. 2013;80(23):2138–44.PubMedPubMedCentralCrossRef
21.
22.
Timmann D, Drepper J, Frings M, Maschke M, Richter S, Gerwig M, et al. The human cerebellum contributes to motor, emotional and cognitive associative learning. A review. Cortex. 2010;46(7):845–57.PubMedCrossRef
23.
Moulton EA, Schmahmann JD, Becerra L, Borsook D. The cerebellum and pain: passive integrator or active participator? Brain Res Rev. 2010;65(1):14–27.PubMedPubMedCentralCrossRef
24.
Bocci T, Santarcangelo E, Vannini B, Torzini A, Carli G, Ferrucci R, et al. Cerebellar direct current stimulation modulates pain perception in humans. Restor Neurol Neurosci. 2015;33(5):597–609.PubMed
25.
Pereira M, Rafiq B, Chowdhury E, Babayev J, Boo H, Metwaly R, et al. Anodal cerebellar tDCS modulates lower extremity pain perception. NeuroRehabilitation. 2017;40(2):195–200.PubMedCrossRef
26.
Bocci T, De Carolis G, Ferrucci R, Paroli M, Mansani F, Priori A, et al. Cerebellar Transcranial direct current stimulation (ctDCS) ameliorates phantom limb pain and non-painful phantom limb sensations. Cerebellum. 2019;18(3):527–35.PubMedCrossRef
27.
Kros L, AngueyraAristizábal CA, Khodakhah K. Cerebellar involvement in migraine. Cephalalgia. 2018;38(11):1782–91.PubMedCrossRef
28.
Mehnert J, Schulte L, Timmann D, May A. Activity and connectivity of the cerebellum in trigeminal nociception. Neuroimage. 2017;150:112–8.PubMedCrossRef
29.
Koppen H, Boele H-J, Palm-Meinders IH, Koutstaal BJ, Horlings CGC, Koekkoek BK, et al. Cerebellar function and ischemic brain lesions in migraine patients from the general population. Cephalalgia. 2016;37(2):177–90.PubMedPubMedCentralCrossRef
30.
Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA. 2004;291(4):427–34.PubMedCrossRef
31.
Liu HY, Lee PL, Chou KH, Lai KL, Wang YF, Chen SP, et al. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine. J Headache Pain. 2020;21(1):29.PubMedPubMedCentralCrossRef
32.
33.
Bilgiç B, Kocaman G, Arslan B, Noyan H, Sherifov R, Alkan A, et al. Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine. Cephalalgia. 2016;36(4):301–8.PubMedCrossRef
34.
35.
Kruit MC, Launer LJ, Overbosch J, van Buchem MA, Ferrari MD. Iron accumulation in deep brain nuclei in migraine: a population-based magnetic resonance imaging study. Cephalalgia. 2009;29:351–9.PubMedCrossRef
36.
Yuan K, Zhao L, Cheng P, Yu D, Zhao L, Dong T, et al. Altered structure and resting-state functional connectivity of the basal ganglia in migraine patients without aura. J Pain. 2013;14:836–44.PubMedCrossRef
37.
Rocca MA, Messina R, Colombo B, Falini A, Comi G, Filippi M. Structural brain MRI abnormalities in pediatric patients with migraine. J Neurol. 2014;261:350–7.PubMedCrossRef
38.
Magon S, May A, Stankewitz A, Goadsby PJ, Tso AR, Ashina M, et al. Morphological abnormalities of thalamic subnuclei in migraine: a multicenter MRI study at 3 Tesla. J Neurosci. 2015;35:13800–6.PubMedPubMedCentralCrossRef
39.
Schmitz N, Arkink EB, Mulder M, Rubia K, Admiraal-Behloul F, Schoonman GG, et al. Frontal lobe structure and executive function in migraine patients. Neurosci Lett. 2008;440:92–6.PubMedCrossRef
40.
Younis S, Hougaard A, Noseda R, Ashina M. Current understanding of thalamic structure and function in migraine. Cephalalgia. 2019;39:1675–82.PubMedCrossRef
41.
Granziera C, Daducci A, Romascano D, Roche A, Helms G, Krueger G, et al. Structural abnormalities in the thalamus of migraineurs with aura: a multiparametric study at 3 T. Hum Brain Mapp. 2014;35:1461–8.PubMedCrossRef
42.
Marciszewski KK, Meylakh N, Di Pietro F, Macefield VG, Macey PM, Henderson LA. Altered brainstem anatomy in migraine. Cephalalgia. 2018;38:476–86.PubMedCrossRef
43.
44.
Chen ZY, Chen XY, Liu MQ, Ma L, Yu SY. Volume gain of brainstem on medication-overuse headache using voxel-based morphometry. Chin Med J (Engl). 2018;131:21582163.
45.
46.
Chong CD, Dumkrieger GM, Schwedt TJ. Structural co-variance patterns in migraine: a cross-sectional study exploring the role of thehippocampus. Headache. 2017;57(10):1522–31.PubMedPubMedCentralCrossRef
47.
Hubbard CS, Khan SA, Keaser ML, Mathur VA, Goyal M, Seminowicz DA. Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients. eNeuro. 2014;1(1):e20.14.PubMedCrossRef
48.
Liu HY, Chou KH, Lee PL, Fuh JL, Niddam DM, Lai KL, et al. Hippocampus and amygdala volume in relation to migraine frequency and prognosis. Cephalalgia. 2016;37(14):1329–36.PubMedCrossRef
49.
Liu J, Lan L, Mu J, Zhao L, Yuan K, Zhang Y, et al. Genetic contributionofcatechol-O-methyltransferaseinhippocampalstructural and functional changes of female migraine sufferers. Hum Brain Mapp. 2015;36(5):1782–95.PubMedPubMedCentralCrossRef
50.
Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013;218(4):903–12.PubMedCrossRef
51.
Liu J, Lan L, Li G, Yan X, Nan J, Xiong S, et al. Migraine-related gray matter and white matter changes at a 1-year follow-up evaluation. J Pain. 2013;14(12):1703–8.PubMedCrossRef
52.
Coppola G, Petolicchio B, Di Renzo A, Tinelli E, Di Lorenzo C, Parisi V, et al. Cerebral gray matter volume in patients with chronic migraine: correlations with clinical features. J Headache Pain. 2017;18:115.PubMedPubMedCentralCrossRef
53.
Neeb L, Bastian K, Villringer K, Israel H, Reuter U, Fiebach JB. Structural gray matter alterations in chronic migraine: implications for a progressive disease? Headache. 2017;57:400416.CrossRef
54.
Schulte LH, Allers A, May A. Hypothalamus as a mediator of chronic migraine: evidence from high-resolution fMRI. Neurology. 2017;88:2011–6.PubMedCrossRef
55.
Androulakis XM, Krebs KA, Jenkins C, Maleki N, Finkel AG, Rorden C, et al. Central executive and default mode network intranet work functional connectivity patterns in chronic migraine. J Neurol Disord. 2018;6:393.PubMedPubMedCentralCrossRef
56.
Domínguez C, López A, Ramos-Cabrer P, Vieites-Prado A, Pérez-Mato M, Villalba C, et al. Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine. Neurology. 2019;92:e1076–85.PubMedCrossRef
57.
Lee MJ, Park BY, Cho S, Kim ST, Park H, Chung CS. Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study. J Headache Pain. 2019;20:29.PubMedPubMedCentralCrossRef
58.
Woldeamanuel YW, DeSouza DD, Sanjanwala BM, Cowan RP. Clinical features contributing to cortical thickness changes in chronic migraine—a pilot study. Headache. 2019;59:180–91.PubMedCrossRef
59.
Kim JH, Suh SI, Seol HY, Oh K, Seo WK, Yu SW, et al. Regional grey matter changes in patients with migraine: a voxel-based morphometry study. Cephalalgia. 2008;28:598–604.PubMedCrossRef
60.
Valfrè W, Rainero I, Bergui M, Pinessi L. Voxel-based morphometry reveals gray matter abnormalities in migraine. Headache. 2008;48:109–17.PubMedCrossRef
61.
Ong WY, Stohler CS, Herr DR. Role of the prefrontal cortex in pain processing. Mol Neurobiol. 2019;56:1137–66.PubMedCrossRef
62.
Krummenacher P, Candia V, Folkers G, Schedlowski M, Schönbächler G. Prefrontal cortex modulates placebo analgesia. Pain. 2010;148:368–74.PubMedCrossRef
63.
Bräscher AK, Becker S, Hoeppli ME, Schweinhardt P. Different brain circuitries mediating controllable and uncontrollable pain. J Neurosci. 2016;36:5013–25.PubMedPubMedCentralCrossRef
64.
65.
May A. Experience-dependent structural plasticity in the adult human brain. Trends Cogn Sci. 2011;15:475–82.PubMedCrossRef
Metadata
Title
A volumetric magnetic resonance imaging study in migraine
Authors
Laila Elmously Naguib
Ghada Saed Abdel Azim
Mohammed Abdelrazek Abdellatif
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1186/s41983-021-00372-7

Other articles of this Issue 1/2021

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2021 Go to the issue

Case Report

Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report

Research

Impact of body mass index on duplex parameters of cranial vessels among the Egyptian population

Letter to the Editor

Reply to Letter to Editor: Is SARS-CoV-2 responsible for relapses of Parkinson’s disease?

Case Report

Rare case of recurrent stroke in a patient with eosinophilic granulomatosis with polyangiitis: a case report

Case Report

Sequential approach of internal maxillary-to-middle cerebral artery bypass and endovascular occlusion for giant middle cerebral artery aneurysm: a case report

Research

Retractorless brain surgery: technical considerations