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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 7/2012

Open Access 01-10-2012 | Tutorial

Migraine headache: a review of the molecular genetics of a common disorder

Authors: Cherubino Di Lorenzo, Gaetano S. Grieco, Filippo M. Santorelli

Published in: The Journal of Headache and Pain | Issue 7/2012

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Abstract

This tutorial summarises the state-of-the-art on migraine genetics and looks at the possible future direction of this field of research. The view of migraine as a genetic disorder, initially based on epidemiological observations of transmission of the condition within families, was subsequently confirmed by the identification of monogenic forms of “syndromic” migraine, such as familial hemiplegic migraine. We are currently witnessing a change in the way genetic analysis is used in migraine research: rather than studying modalities of inheritance in non-monogenic forms of migraine and in the persistent modalities of migraine headache, researchers are now tending to focus on the search for genetic markers of dysfunction in biological systems. One example of the evolution of migraine genetic research is provided by the recent efforts to shed light on the pharmacogenomic mechanisms of drug response in migraineurs. In addition, novel molecular approaches about to be introduced are expected to further increase knowledge on this topic and improve patient management.
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Metadata
Title
Migraine headache: a review of the molecular genetics of a common disorder
Authors
Cherubino Di Lorenzo
Gaetano S. Grieco
Filippo M. Santorelli
Publication date
01-10-2012
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 7/2012
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-012-0478-x

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