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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2021

Open Access 01-12-2021 | Mifepristone | Research

Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure

Authors: Li Zhou, Chenggang Li, Xiangshu Liu, Tao Zhang

Published in: Reproductive Biology and Endocrinology | Issue 1/2021

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Abstract

Objective

The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.

Methods

Early pregnant rats were randomly divided into normal group (N), mifepristone treated group (M), irisin group (I) and progestin group (P). The implantation failure model was established using mifepristone. Second, we evaluated the average number of embryos and detected the expression of LIF and integrin αvβ3 protein and mRNA in endometrium.

Results

Compared with group M, the average number of embryos was significantly higher in group N, P and I, the expression of LIF and integrin αvβ3 in endometrium was significantly higher in group N, P and I.

Conclusion

Irisin could improve the poor receptive state of endometrium by promoting LIF and integrin αvβ3 secretion to improve blastocyst implantation in rats of implantation failure.
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Metadata
Title
Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
Authors
Li Zhou
Chenggang Li
Xiangshu Liu
Tao Zhang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2021
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-021-00700-9

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