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Rheumatology International
Published in: Rheumatology International 3/2013

01-03-2013 | Review

MicroRNA-155 as a therapeutic target for inflammatory diseases

Authors: Naghmana Kanwal, Peter John, Attya Bhatti

Published in: Rheumatology International | Issue 3/2013

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Abstract

MicroRNAs are short non-coding molecules expressed in different tissues and regulate the transcription of different genes. They are highly specific in their action. Upregulation or downregulation of specific microRNAs has been observed during different diseases like cancers, embryogenesis, organogenesis, apoptosis and arthritis. They are also known to be involved in autoimmune diseases. MicroRNAs are also found to be stable and easy to validate. Differential expression of microRNA-155 has been studied by different groups in inflammatory diseases including arthritis along with other miRNAs. This suggests that it can be used as a potential biomarker or therapeutic in the autoimmune diseases, especially rheumatoid arthritis. Experimental studies are needed to explore their role as biomarker or therapeutic.
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Metadata
Title
MicroRNA-155 as a therapeutic target for inflammatory diseases
Authors
Naghmana Kanwal
Peter John
Attya Bhatti
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 3/2013
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-012-2559-1

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