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Seminars in Immunopathology
Published in: Seminars in Immunopathology 5/2011

01-09-2011 | Review

Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis

Authors: Olivier Morel, Nicolas Morel, Laurence Jesel, Jean-Marie Freyssinet, Florence Toti

Published in: Seminars in Immunopathology | Issue 5/2011

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Abstract

Plasma membrane remodeling characterized by phosphatidylserine exposure and consecutive microparticle (MP) shedding is an ubiquitous process enabling the clearance of senescent cells and the maintenance of tissue homeostasis. MPs are released as fragments from the budding plasma membrane of virtually all eukaryotic cell types undergoing stimulation or apoptosis and may be considered a broad primitive response to stress. MP release is dependent on cytoskeleton degradation pathways involving caspases, requires a sustained increase in intracellular calcium triggering K+ and Cl− efflux and is possibly tuned by mitochondria permeability changes. Because they convey a broad spectrum of bioactive molecules, circulating MPs may serve as shuttles promoting cellular cross talk in various pathological settings such as inflammation or immunity-induced thrombotic disorders. If the drastic shedding of procoagulant MPs appears clearly noxious in thrombotic disorders or in some models of inflammation-induced coagulopathy, this does not necessarily endorse their invariably harmful nature. In the vessel, endothelial cytoprotection reported in the early regulation of inflammation-induced coagulopathy is emblematic of the beneficial effects provided by MPs. In addition, MPs would prove beneficial in the prevention of blood leakage. Because of their multiple properties that are characteristic of a private response of the parental cell, MPs could act as cytoprotective and anti-inflammatory agents through the delivery of activated protein C or annexin 1 and could contribute to the limitation of vascular hyporeactivity. Owing to their ability to cargo bioactive signals, MPs could be viewed as an integrated communication network enabling the coordination of complex cellular responses in biological fluids and the maintenance of the homeostasis equation. A better understanding of the molecular mechanisms involved in MP shedding would pave the way of a new pharmacological approach aiming at the control of MP-driven cellular responses.
Literature
1.
Freyssinet JM, Toti F, Hugel B et al (1999) Apoptosis in vascular disease. Thromb Haemost 82:727–735PubMed
2.
Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM (2000) A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 405:85–90PubMed
3.
Bevers EM, Williamson PL (2010) Phospholipid scramblase: an update. FEBS Lett 584:2724–2730PubMed
4.
Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM (2005) Membrane microparticles: two sides of the coin. Physiology (Bethesda) 20:22–27
5.
Seigneuret M, Zachowski A, Hermann A, Devaux PF (1984) Asymmetric lipid fluidity in human erythrocyte membrane: new spin-label evidence. Biochemistry 23:4271–4275PubMed
6.
Smeets EF, Comfurius P, Bevers EM, Zwaal RF (1994) Calcium-induced transbilayer scrambling of fluorescent phospholipid analogs in platelets and erythrocytes. Biochim Biophys Acta 1195:281–286PubMed
7.
Williamson P, Bevers EM, Smeets EF, Comfurius P, Schlegel RA, Zwaal RF (1995) Continuous analysis of the mechanism of activated transbilayer lipid movement in platelets. Biochemistry 34:10448–10455PubMed
8.
Comfurius P, Williamson P, Smeets EF, Schlegel RA, Bevers EM, Zwaal RF (1996) Reconstitution of phospholipid scramblase activity from human blood platelets. Biochemistry 35:7631–7634PubMed
9.
Sinauridze EI, Kireev DA, Popenko NY et al (2007) Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost 97:425–434PubMed
10.
Weiss HJ, Vicic WJ, Lages BA, Rogers J (1979) Isolated deficiency of platelet procoagulant activity. Am J Med 67:206–213PubMed
11.
Toti F, Satta N, Fressinaud E, Meyer D, Freyssinet JM (1996) Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications, is an inherited disorder. Blood 87:1409–1415PubMed
12.
Brooks MB, Catalfamo JL, Brown HA, Ivanova P, Lovaglio J (2002) A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity. Blood 99:2434–2441PubMed
13.
Varga-Szabo D, Braun A, Nieswandt B (2009) Calcium signaling in platelets. J Thromb Haemost 7:1057–1066PubMed
14.
Braun A, Varga-Szabo D, Kleinschnitz C et al (2009) Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood 113:2056–2063PubMed
15.
Varga-Szabo D, Braun A, Kleinschnitz C et al (2008) The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J Exp Med 205:1583–1591PubMed
16.
Muik M, Frischauf I, Derler I et al (2008) Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J Biol Chem 283:8014–8022PubMed
17.
Le Goff W, Peng DQ, Settle M, Brubaker G, Morton RE, Smith JD (2004) Cyclosporin A traps ABCA1 at the plasma membrane and inhibits ABCA1-mediated lipid efflux to apolipoprotein A-I. Arterioscler Thromb Vasc Biol 24:2155–2161PubMed
18.
Lorenzi I, von Eckardstein A, Cavelier C, Radosavljevic S, Rohrer L (2008) Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI. J Mol Med 86:171–183PubMed
19.
Karwatsky J, Ma L, Dong F, Zha X (2009) Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+ dependent-calcineurin signaling. J Lipid Res 51(5):1144–1156PubMed
20.
Cauwenberghs S, Feijge MA, Harper AG, Sage SO, Curvers J, Heemskerk JW (2006) Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton. FEBS Lett 580:5313–5320PubMed
21.
Sebbagh M, Renvoize C, Hamelin J, Riche N, Bertoglio J, Breard J (2001) Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol 3:346–352PubMed
22.
Sapet C, Simoncini S, Loriod B et al (2006) Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood 108:1868–1876PubMed
23.
Simoncini S, Njock MS, Robert S et al (2009) TRAIL/Apo2L mediates the release of procoagulant endothelial microparticles induced by thrombin in vitro: a potential mechanism linking inflammation and coagulation. Circ Res 104:943–951PubMed
24.
Michel V, Bakovic M (2007) Lipid rafts in health and disease. Biol Cell 99:129–140PubMed
25.
Kunzelmann-Marche C, Freyssinet JM, Martinez MC (2002) Loss of plasma membrane phospholipid asymmetry requires raft integrity. Role of transient receptor potential channels and ERK pathway. J Biol Chem 277:19876–19881PubMed
26.
Connor DE, Exner T, Ma DD, Joseph JE (2010) The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb Haemost 103:1044–1052PubMed
27.
Perez-Pujol S, Marker PH, Key NS (2007) Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytom A 71:38–45
28.
Baj-Krzyworzeka M, Majka M, Pratico D et al (2002) Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. Exp Hematol 30:450–459PubMed
29.
Elliott JI, Sardini A, Cooper JC et al (2006) Phosphatidylserine exposure in B lymphocytes: a role for lipid packing. Blood 108:1611–1617PubMed
30.
Contreras FX, Villar AV, Alonso A, Kolesnick RN, Goni FM (2003) Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes. J Biol Chem 278:37169–37174PubMed
31.
Devaux PF, Lopez-Montero I, Bryde S (2006) Proteins involved in lipid translocation in eukaryotic cells. Chem Phys Lipids 141:119–132PubMed
32.
Lang F, Gulbins E, Lang PA, Zappulla D, Foller M (2010) Ceramide in suicidal death of erythrocytes. Cell Physiol Biochem 26:21–28PubMed
33.
Elliott JI, Higgins CF (2003) IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis. EMBO Rep 4:189–194PubMed
34.
Skals M, Jensen UB, Ousingsawat J, Kunzelmann K, Leipziger J, Praetorius HA (2010) Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure. J Biol Chem 285:15557–15565PubMed
35.
Wolfs JL, Wielders SJ, Comfurius P et al (2006) Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel. Blood 108(7):2223–2228PubMed
36.
Suzuki J, Umeda M, Sims PJ, Nagata S (2010) Calcium-dependent phospholipid scrambling by TMEM16F. Nature 468:834–838PubMed
37.
Castoldi E, Collins PW, Williamson PL, Bevers EM (2011) Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome. Blood 117(16):4399–4400
38.
Bucki R, Pastore JJ, Giraud F, Janmey PA, Sulpice JC (2006) Involvement of the Na+/H + exchanger in membrane phosphatidylserine exposure during human platelet activation. Biochim Biophys Acta 1761:195–204PubMed
39.
Leytin V, Allen DJ, Mutlu A, Gyulkhandanyan AV, Mykhaylov S, Freedman J (2009) Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. Lab Invest 89:374–384PubMed
40.
Halestrap AP, Davidson AM (1990) Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem J 268:153–160PubMed
41.
Dale GL, Friese P (2006) Bax activators potentiate coated-platelet formation. J Thromb Haemost 4:2664–2669PubMed
42.
Lopez JJ, Salido GM, Pariente JA, Rosado JA (2008) Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets. J Thromb Haemost 6:1780–1788PubMed
43.
Baines CP, Kaiser RA, Purcell NH et al (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434:658–662PubMed
44.
Brooks M, Etter K, Catalfamo J, Brisbin A, Bustamante C, Mezey J (2010) A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27. Gene 450:70–75PubMed
45.
Jimenez JJ, Jy W, Mauro LM, Soderland C, Horstman LL, Ahn YS (2003) Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res 109:175–180PubMed
46.
Bernimoulin M, Waters EK, Foy M et al (2009) Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost 7:1019–1028PubMed
47.
Mause SF, Weber C (2010) Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 107:1047–1057PubMed
48.
Giesen PL, Rauch U, Bohrmann B et al (1999) Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci USA 96:2311–2315PubMed
49.
Ettelaie C, Collier ME, James NJ, Li C (2007) Induction of tissue factor expression and release as microparticles in ECV304 cell line by Chlamydia pneumoniae infection. Atherosclerosis 190:343–351PubMed
50.
Kushak RI, Nestoridi E, Lambert J, Selig MK, Ingelfinger JR, Grabowski EF (2005) Detached endothelial cells and microparticles as sources of tissue factor activity. Thromb Res 116:409–419PubMed
51.
Morel O, Ohlmann P, Epailly E et al (2008) Endothelial cell activation contributes to the release of procoagulant microparticles during acute cardiac allograft rejection. J Heart Lung Transplant 27:38–45PubMed
52.
Ramacciotti E, Hawley AE, Farris DM et al (2009) Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis. Thromb Haemost 101:748–754PubMed
53.
Morel O, Pereira B, Averous G et al (2009) Increased levels of procoagulant tissue factor-bearing microparticles within the occluded coronary artery of patients with ST-segment elevation myocardial infarction: role of endothelial damage and leukocyte activation. Atherosclerosis 204:636–641PubMed
54.
Morel N, Morel O, Petit L et al (2008) Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J Trauma 64:698–704PubMed
55.
Smalheiser NR (2009) Do neural cells communicate with endothelial cells via secretory exosomes and microvesicles? Cardiovasc Psychiatry Neurol 2009:383086PubMed
56.
van Beers EJ, Schaap MC, Berckmans RJ et al (2009) Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease. Haematologica 94:1513–1519PubMed
57.
Pankoui Mfonkeu JB, Gouado I, Fotso Kuate H et al (2010) Elevated cell-specific microparticles are a biological marker for cerebral dysfunctions in human severe malaria. PLoS One 5:e13415PubMed
58.
Mesri M, Altieri DC (1999) Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway. J Biol Chem 274:23111–23118PubMed
59.
Essayagh S, Xuereb JM, Terrisse AD, Tellier-Cirioni L, Pipy B, Sie P (2007) Microparticles from apoptotic monocytes induce transient platelet recruitment and tissue factor expression by cultured human vascular endothelial cells via a redox-sensitive mechanism. Thromb Haemost 98:831–837PubMed
60.
Mause SF, von Hundelshausen P, Zernecke A, Koenen RR, Weber C (2005) Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol 25:1512–1518PubMed
61.
Bakouboula B, Morel O, Faure A et al (2008) Procoagulant membrane microparticles correlate with the severity of pulmonary arterial hypertension. Am J Respir Crit Care Med 177:536–543PubMed
62.
Diehl P, Aleker M, Helbing T, et al (2010) Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension. J Thromb Thrombolysis (in press)
63.
Polgar J, Matuskova J, Wagner DD (2005) The P-selectin, tissue factor, coagulation triad. J Thromb Haemost 3:1590–1596PubMed
64.
Hrachovinova I, Cambien B, Hafezi-Moghadam A et al (2003) Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med 9:1020–1025PubMed
65.
Del Conde I, Nabi F, Tonda R, Thiagarajan P, Lopez JA, Kleiman NS (2005) Effect of P-selectin on phosphatidylserine exposure and surface-dependent thrombin generation on monocytes. Arterioscler Thromb Vasc Biol 25:1065–1070PubMed
66.
Celi A, Lorenzet R, Furie BC, Furie B (2004) Microparticles and a P-selectin-mediated pathway of blood coagulation. Dis Markers 20:347–352PubMed
67.
Celi A, Pellegrini G, Lorenzet R et al (1994) P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci USA 91:8767–8771PubMed
68.
Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B (2002) Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med 8:1175–1181PubMed
69.
Falati S, Liu Q, Gross P et al (2003) Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 197:1585–1598PubMed
70.
Thomas GM, Panicot-Dubois L, Lacroix R, Dignat-George F, Lombardo D, Dubois C (2009) Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo. J Exp Med 206:1913–1927PubMed
71.
Mallat Z, Hugel B, Ohan J, Leseche G, Freyssinet JM, Tedgui A (1999) Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation 99:348–353PubMed
72.
Llorente-Cortes V, Otero-Vinas M, Camino-Lopez S, Llampayas O, Badimon L (2004) Aggregated low-density lipoprotein uptake induces membrane tissue factor procoagulant activity and microparticle release in human vascular smooth muscle cells. Circulation 110:452–459PubMed
73.
Mayr M, Grainger D, Mayr U et al (2009) Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques. Circ Cardiovasc Genet 2:379–388PubMed
74.
Nemerson Y (2002) A simple experiment and a weakening paradigm: the contribution of blood to propensity for thrombus formation. Arterioscler Thromb Vasc Biol 22:1369PubMed
75.
Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B (2004) Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood 104:3190–3197PubMed
76.
Day SM, Reeve JL, Pedersen B et al (2005) Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood 105:192–198PubMed
77.
Leroyer AS, Rautou PE, Silvestre JS et al (2008) CD40 ligand + microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization. J Am Coll Cardiol 52:1302–1311PubMed
78.
Virmani R, Kolodgie FD, Burke AP et al (2005) Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 25:2054–2061PubMed
79.
Mause SF, Ritzel E, Liehn EA et al (2010) Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 122:495–506PubMed
80.
Taraboletti G, D'Ascenzo S, Borsotti P, Giavazzi R, Pavan A, Dolo V (2002) Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. Am J Pathol 160:673–680PubMed
81.
Dejouvencel T, Doeuvre L, Lacroix R et al (2010) Fibrinolytic cross-talk: a new mechanism for plasmin formation. Blood 115:2048–2056PubMed
82.
Doeuvre L, Plawinski L, Goux D, Vivien D, Angles-Cano E (2010) Plasmin on adherent cells: from microvesiculation to apoptosis. Biochem J 432:365–373PubMed
83.
Lacroix R, Sabatier F, Mialhe A et al (2007) Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. Blood 110:2432–2439PubMed
84.
Canault M, Leroyer AS, Peiretti F et al (2007) Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am J Pathol 171:1713–1723PubMed
85.
Satta N, Freyssinet JM, Toti F (1997) The significance of human monocyte thrombomodulin during membrane vesiculation and after stimulation by lipopolysaccharide. Br J Haematol 96:534–542PubMed
86.
Sabatier F, Roux V, Anfosso F, Camoin L, Sampol J, Dignat-George F (2002) Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity. Blood 99:3962–3970PubMed
87.
Kasthuri RS, Taubman MB, Mackman N (2009) Role of tissue factor in cancer. J Clin Oncol 27:4834–4838PubMed
88.
Manly DA, Boles J, Mackman N (2010) Role of tissue factor in venous thrombosis. Annu Rev Physiol (in press)
89.
Manly DA, Wang J, Glover SL et al (2010) Increased microparticle tissue factor activity in cancer patients with venous thromboembolism. Thromb Res 125:511–512PubMed
90.
Zhou J, May L, Liao P, Gross PL, Weitz JI (2009) Inferior vena cava ligation rapidly induces tissue factor expression and venous thrombosis in rats. Arterioscler Thromb Vasc Biol 29:863–869PubMed
91.
Szalony JA, Suleymanov OD, Salyers AK et al (2003) Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time. Thromb Res 112:167–174PubMed
92.
Ay C, Simanek R, Vormittag R et al (2008) High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS). Blood 112:2703–2708PubMed
93.
Zwicker JI, Liebman HA, Neuberg D et al (2009) Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res 15:6830–6840PubMed
94.
Tesselaar ME, Romijn FP, van der Linden IK, Bertina RM, Osanto S (2009) Microparticle-associated tissue factor activity in cancer patients with and without thrombosis. J Thromb Haemost 7:1421–1423PubMed
95.
Bulut D, Maier K, Bulut-Streich N, Borgel J, Hanefeld C, Mugge A (2008) Circulating endothelial microparticles correlate inversely with endothelial function in patients with ischemic left ventricular dysfunction. J Card Fail 14:336–340PubMed
96.
Werner N, Wassmann S, Ahlers P, Kosiol S, Nickenig G (2005) Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 26:112PubMed
97.
Pfister SL (2004) Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery. Hypertension 43:428–433PubMed
98.
Martin S, Tesse A, Hugel B et al (2004) Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation 109:1653–1659PubMed
99.
Essayagh S, Brisset AC, Terrisse AD et al (2005) Microparticles from apoptotic vascular smooth muscle cells induce endothelial dysfunction, a phenomenon prevented by beta3-integrin antagonists. Thromb Haemost 94:853–858PubMed
100.
Hugel B, Socie G, Vu T et al (1999) Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia. Blood 93:3451–3456PubMed
101.
Jy W, Horstmann LL, Arce M, Ahn YS (1992) Clinical significance of platelet microparticles in autoimmune thrombocytopenias. J Lab Clin Med 119:334–345PubMed
102.
Proulle V, Hugel B, Guillet B et al (2004) Injection of recombinant activated factor VII can induce transient increase in circulating procoagulant microparticles. Thromb Haemost 91:873–878PubMed
103.
Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB (2009) Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma 66:S69–S76PubMed
104.
Morel N, Delaunay F, Dabadie P, Averous G, Morel O (2010) Damage control resuscitation using warm fresh whole blood: a paramount role for leukocytes and derived microparticles in the prevention of coagulation abnormalities? J Trauma 68:1266–1267, author reply 1267PubMed
105.
Huisse MG, Pease S, Hurtado-Nedelec M et al (2008) Leukocyte activation: the link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris. Crit Care Med 36:2288–2295PubMed
106.
Satta N, Toti F, Feugeas O et al (1994) Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide. J Immunol 153:3245–3255PubMed
107.
Wang JG, Manly D, Kirchhofer D, Pawlinski R, Mackman N (2009) Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice. J Thromb Haemost 7:1092–1098PubMed
108.
Stahl AL, Sartz L, Nelsson A, Bekassy ZD, Karpman D (2009) Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. PLoS ONE 4:e6990PubMed
109.
Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE (2003) Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 188:1618–1629PubMed
110.
Aras O, Shet A, Bach RR et al (2004) Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia. Blood 103:4545–4553PubMed
111.
Barry OP, Pratico D, Lawson JA, FitzGerald GA (1997) Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest 99:2118–2127PubMed
112.
Mesri M, Altieri DC (1998) Endothelial cell activation by leukocyte microparticles. J Immunol 161:4382–4387PubMed
113.
Nomura S, Tandon NN, Nakamura T, Cone J, Fukuhara S, Kambayashi J (2001) High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis 158:277–287PubMed
114.
Müller F, Mutch NJ, Schenk WA, Smith SA, Esterl L, Spronk HM, Schmidbauer S, Gahl WA, Morrissey JH, Renne T (2009) Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 139:1143–1156
115.
Jy W, Mao WW, Horstman L, Tao J, Ahn YS (1995) Platelet microparticles bind, activate and aggregate neutrophils in vitro. Blood Cells Mol Dis 21:217–231, discussion 231aPubMed
116.
MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A (2001) Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15:825–835PubMed
117.
Scanu A, Molnarfi N, Brandt KJ, Gruaz L, Dayer JM, Burger D (2008) Stimulated T cells generate microparticles, which mimic cellular contact activation of human monocytes: differential regulation of pro- and anti-inflammatory cytokine production by high-density lipoproteins. J Leukoc Biol 83:921–927PubMed
118.
Carpintero R, Gruaz L, Brandt KJ et al (2010) HDL interfere with the binding of T cell microparticles to human monocytes to inhibit pro-inflammatory cytokine production. PLoS One 5:e11869PubMed
119.
Berckmans RJ, Nieuwland R, Kraan MC et al (2005) Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes. Arthritis Res Ther 7:R536–R544PubMed
120.
Berckmans RJ, Nieuwland R, Tak PP et al (2002) Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism. Arthritis Rheum 46:2857–2866PubMed
121.
Boilard E, Nigrovic PA, Larabee K et al (2010) Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327:580–583PubMed
122.
Combes V, Taylor TE, Juhan-Vague I et al (2004) Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma. JAMA 291:2542–2544PubMed
123.
Combes V, Coltel N, Alibert M et al (2005) ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology. Am J Pathol 166:295–302PubMed
124.
Faille D, Combes V, Mitchell AJ et al (2009) Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium. FASEB J 23:3449–3458PubMed
125.
Densmore JC, Signorino PR, Ou J et al (2006) Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury. Shock 26:464–471PubMed
126.
Buesing KL, Densmore JC, Kaul S, et al (2010) Endothelial Microparticles Induce Inflammation in Acute Lung Injury. J Surg Res (in press)
127.
Gambim MH, do Carmo Ade O, Marti L, Verissimo-Filho S, Lopes LR, Janiszewski M (2007) Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction. Crit Care 11:R107PubMed
128.
Mortaza S, Martinez MC, Baron-Menguy C et al (2009) Detrimental hemodynamic and inflammatory effects of microparticles originating from septic rats. Crit Care Med 37:2045–2050PubMed
129.
Abid Hussein MN, Boing AN, Sturk A, Hau CM, Nieuwland R (2007) Inhibition of microparticle release triggers endothelial cell apoptosis and detachment. Thromb Haemost 98:1096–1107PubMed
130.
Gasser O, Schifferli JA (2004) Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104:2543–2548PubMed
131.
Sadallah S, Eken C, Schifferli JA (2008) Erythrocyte-derived ectosomes have immunosuppressive properties. J Leukoc Biol 84:1316–1325PubMed
132.
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY, Perretti M (2008) Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood 112:2512–2519PubMed
133.
Dalli J, Rosignoli G, Hayhoe RP, Edelman A, Perretti M (2010) CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway. Am J Pathol 177:176–186PubMed
134.
Morel O, Morel N, Freyssinet JM, Toti F (2008) Platelet microparticles and vascular cells interactions: a checkpoint between the haemostatic and thrombotic responses. Platelets 19:9–23PubMed
135.
Perez-Casal M, Downey C, Fukudome K, Marx G, Toh CH (2005) Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood 105:1515–1522PubMed
136.
Pérez-Casal M, Downey C, Cutillas-Moreno B, Zuzel B, Fukudome K, Hock Toh C (2010) Microparticle-associated endothelial protein C receptor induces cytoprotective and anti-inflammatory effects. Haematologica (in press)
137.
Mosnier LO, Zlokovic BV, Griffin JH (2007) The cytoprotective protein C pathway. Blood 109:3161–3172PubMed
138.
Bouchama A, Kunzelmann C, Dehbi M et al (2008) Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke. Arterioscler Thromb Vasc Biol 28:1318–1325PubMed
139.
Mostefai HA, Meziani F, Mastronardi ML et al (2008) Circulating microparticles from patients with septic shock exert protective role in vascular function. Am J Respir Crit Care Med 178:1148–1155PubMed
140.
Nieuwland R, Berckmans RJ, McGregor S et al (2000) Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood 95:930–935PubMed
141.
Soriano AO, Jy W, Chirinos JA et al (2005) Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis. Crit Care Med 33:2540–2546PubMed
142.
Sennoun N, Baron-Menguy C, Burban M et al (2009) Recombinant human activated protein C improves endotoxemia-induced endothelial dysfunction: a blood-free model in isolated mouse arteries. Am J Physiol Heart Circ Physiol 297:H277–H282PubMed
143.
Sadallah S, Eken C, Schifferli JA (2010) Ectosomes as modulators of inflammation and immunity. Clin Exp Immunol 163:26–32PubMed
144.
Pisetsky DS, Lipsky PE (2010) Microparticles as autoadjuvants in the pathogenesis of SLE. Nat Rev Rheumatol 6:368–372PubMed
145.
Abrahams VM, Straszewski-Chavez SL, Guller S, Mor G (2004) First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Mol Hum Reprod 10:55–63PubMed
146.
Abrahams VM, Straszewski SL, Kamsteeg M et al (2003) Epithelial ovarian cancer cells secrete functional Fas ligand. Cancer Res 63:5573–5581PubMed
147.
Castellana D, Zobairi F, Martinez MC et al (2009) Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res 69:785–793PubMed
Metadata
Title
Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis
Authors
Olivier Morel
Nicolas Morel
Laurence Jesel
Jean-Marie Freyssinet
Florence Toti
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 5/2011
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-010-0239-3

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