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01-06-2013 | Review

Microbes, the gut and ankylosing spondylitis

Authors: Mary-Ellen Costello, Dirk Elewaut, Tony J Kenna, Matthew A Brown

Published in: Arthritis Research & Therapy | Issue 3/2013

Abstract

It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intestine contains approximately 100 trillion bacteria. Interrogation of microbial communities by using classic microbiology techniques offers a very restricted view of these communities, allowing us to see only what we can grow in isolation. However, recent advances in sequencing technologies have greatly facilitated systematic and comprehensive studies of the role of the microbiome in human health and disease. Comprehensive understanding of our microbiome will enhance understanding of disease pathogenesis, which in turn may lead to rationally targeted therapy for a number of conditions, including autoimmunity.

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Title: Microbes, the gut and ankylosing spondylitis
Authors: Mary-Ellen Costello
Dirk Elewaut
Tony J Kenna
Matthew A Brown
Publication date: 01-06-2013
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 3/2013
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar4228

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