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Journal of General Internal Medicine
Published in: Journal of General Internal Medicine 2/2020

01-02-2020 | Metronidazole | Capsule Commentary

Capsule Commentary on Novosad et al., Treatment of Clostridioides Difficile Infection and Non-compliance with Treatment Guidelines in Adults, 10 US Geographical Locations, 2013–2015

Author: Kelly R. Reveles, PharmD, PhD

Published in: Journal of General Internal Medicine | Issue 2/2020

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Excerpt

This retrospective study by Novosad et al.1 described Clostridioides difficile infection (CDI) antibiotic prescribing practices and adherence to the 2010 IDSA/SHEA CDI treatment recommendations2 using data from the Emerging Infections Program from 2013 to 2015. The investigators found that among the 18,243 CDI cases identified, metronidazole was the most commonly prescribed antibiotic (78%), following by vancomycin (42%), and fidaxomicin (2%). Of particular concern, guideline adherence for severe CDI was only 47%. …
Literature
1.
Novosad SA, Mu Y, Winston LG, Johnston H, Basiliere E, Olson DM, Farley MM, Revis A, Wilson L, Perlmutter R, Holzbauer RM, Whitten T, Phipps EC, Dumyati GK, Beldavs ZG, Ocampo VLS, Davis CM, Kainer M, Gerding DN, Guh AY. Treatment of Clostridioides difficile infection and non-compliance with treatment guidelines in adults, 10 U.S. Geographical Locations, 2013-2015. J Gen Intern Med. https://​doi.​org/​10.​1007/​s11606-019-05386-9.
2.
Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010;31(5):431-55.CrossRef
3.
McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66(7):987-994.CrossRef
4.
Crowell KT, Julian KG, Katzman M, Berg AS, Tinsley A, Williams ED, Koltun WA, Messaris E. Compliance with Clostridium difficile treatment guidelines: effect on patient outcomes. Epidemiol Infect 2017;145(11):2185-2192.CrossRef
5.
Patel I, Wungjiranirun M, Theethira T, Villafuerte-Galvez J, Castillo N, Akbari M, Alonso CD, Leffler DA, Kelly CP. Lack of adherence to SHEA-IDSA treatment guidelines for Clostridium difficile infection is associated with increased mortality. J Antimicrob Chemother 2017;72(2):574-581.CrossRef
Metadata
Title
Capsule Commentary on Novosad et al., Treatment of Clostridioides Difficile Infection and Non-compliance with Treatment Guidelines in Adults, 10 US Geographical Locations, 2013–2015
Author
Kelly R. Reveles, PharmD, PhD
Publication date
01-02-2020
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 2/2020
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-019-05494-6

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