Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2013

Open Access 01-02-2013 | Poster presentation

Methyprednisolone i.v. alters levels of CGRP and melatonin in cluster headache patients

Authors: L Neeb, L Anders, P Euskirchen, J Hoffmann, U Reuter

Published in: The Journal of Headache and Pain | Special Issue 1/2013

Login to get access

Excerpt

Treatment with steroids for short term cluster headache (CH) prophylaxis is a widely accepted therapy. However, the mechanism of action of steroids in CH prophylaxis is unknown. Various studies could show that the trigeminovascular system and the hypothalamus play probably a key role in CH pathophysiology. The neuropeptid calcitonin gene related peptide (CGRP) is released in an acute attack indicating activation of the trigeminovasclular system.[1] The hypothalamus regulates the circadian secretion of melatonin which is reduced in CH patients during a bout.[2] …
Literature
1.
Goadsby PJ, Edvinsson L: Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 1994, 117(Pt 3):427–34.CrossRefPubMed
2.
Leone M, Lucini V, D'Amico D, Grazzi L, Moschiano F, Fraschini F, et al.: Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache. Cephalalgia 1998, 18(10):664–7. 10.1046/j.1468-2982.1998.1810664.xCrossRefPubMed
Metadata
Title
Methyprednisolone i.v. alters levels of CGRP and melatonin in cluster headache patients
Authors
L Neeb
L Anders
P Euskirchen
J Hoffmann
U Reuter
Publication date
01-02-2013
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-14-S1-P63

Other articles of this Special Issue 1/2013

The Journal of Headache and Pain 1/2013 Go to the issue

Poster presentation

Investigation of 5-HT2B receptor induced dural plasma protein extravasation in a mouse migraine model

Poster presentation

Syndrome of headache with neurologic deficits and CSF lymphocytosis (HaNDL)

Oral presentation

Reflections on NICE Headache Guidelines

Poster presentation

Anodal transcranial direct current stimulation of the visual cortex for migraine prevention: a proof-of-concept study

Poster presentation

Corticosterone enhances CSD susceptibility via glucocorticoid receptor activation in familial hemiplegic migraine 1 Cacna1a knock-in mice

Poster presentation

Survey of the differences between Migraine and MOH pre-existing migraine