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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2013

Open Access 01-02-2013 | Poster presentation

Corticosterone enhances CSD susceptibility via glucocorticoid receptor activation in familial hemiplegic migraine 1 Cacna1a knock-in mice

Authors: R Shyti, K Eikermann-Haerter, OC Meijer, SH van Heiningen, L De Groote, MD Ferrari, C Ayata, AMJ van den Maagdenberg, EA Tolner

Published in: The Journal of Headache and Pain | Special Issue 1/2013

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Excerpt

FHM1 mutant mice carrying the R192Q gain-of-function mutation in CaV2.1 (P/Q-type) calcium channels display enhanced glutamatergic transmission and increased propensity for cortical spreading depression (CSD;1,2). Corticosteroids released after stress also enhance glutamatergic transmission but the relationship between stress and migraine is not well understood. …
Literature
1.
van den Maagdenberg AMJM, et al.: A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004, 41: 701–710. 10.1016/S0896-6273(04)00085-6CrossRefPubMed
2.
Tottene A, et al.: Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009, 61: 762–773. 10.1016/j.neuron.2009.01.027CrossRefPubMed
Metadata
Title
Corticosterone enhances CSD susceptibility via glucocorticoid receptor activation in familial hemiplegic migraine 1 Cacna1a knock-in mice
Authors
R Shyti
K Eikermann-Haerter
OC Meijer
SH van Heiningen
L De Groote
MD Ferrari
C Ayata
AMJ van den Maagdenberg
EA Tolner
Publication date
01-02-2013
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-14-S1-P85

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