Methylphenidate-Induced Autoimmune Hepatitis

Excerpt

Autoimmune hepatitis (AIH) is a chronic necroinflammatory disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level [1]. The pathogenesis is proposed to result from a genetically predisposed host being exposed to an environmental agent that triggers an autoimmune process directed at liver antigens causing continued inflammation that results in fibrosis and often cirrhosis [1]. The diagnosis is characterized by serologic markers such as antinuclear antibodies (ANAs), anti-smooth muscle antibody (anti-SMA), antiactin antibody, anti-liver/kidney microsomal antibody (anti-LKMA), and elevated serum globulins, most notably immunoglobulin G (IgG) [1]. Anti-inflammatory/immunosuppressive therapy is effective, with an initial remission rate of 80%, with prognosis inversely proportional to histologic severity of disease [1]. …