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01-02-2007 | Original Paper

Protective Effect of a Novel Rice Extract Against Ethanol-Induced Gastric Mucosal Injury in Rat

Authors: Tamotsu Matsuhashi, Michiro Otaka, Masaru Odashima, Mario Jin, Koga Komatsu, Isao Wada, Youhei Horikawa, Reina Ohba, Jinko Oyake, Natsumi Hatakeyama, Sumio Watanabe

Published in: Digestive Diseases and Sciences | Issue 2/2007

Abstract

The aim of this study was to investigate the protective action of rice extract on ethanol-induced mucosal damage in vivo and wound healing of epithelial cells in vitro. Also, the effect of rice extract on gastric mucosal prostaglandin E₂ level, HSP72 expression, gastric acid secretion, and contribution of vanilloid receptor-mediated action was studied. In addition, using cultured gastric mucosal cells (RGM-1), the effect of rice extract on cytoprotection and wound healing of epithelial cells was evaluated. Rice extract significantly reduced gastric mucosal damage produced by ethanol in vivo, and heat treatment (80°C, 3 min) of this agent did not alter its protective effect. Rice extract also protected RGM-1 from ethanol-induced damage in a dose-dependent manner. Rice extract accelerated wound healing of gastric epithelial cells. Our results demonstrate that rice extract could be an alternative ulcer treatment that provides cytoprotection and enhancement of wound healing not dependent on acid secretion, prostaglandin E₂ level, HSP72 expression, or vanilloid receptors.

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Title: Protective Effect of a Novel Rice Extract Against Ethanol-Induced Gastric Mucosal Injury in Rat
Authors: Tamotsu Matsuhashi
Michiro Otaka
Masaru Odashima
Mario Jin
Koga Komatsu
Isao Wada
Youhei Horikawa
Reina Ohba
Jinko Oyake
Natsumi Hatakeyama
Sumio Watanabe
Publication date: 01-02-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Digestive Diseases and Sciences / Issue 2/2007
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9571-9

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