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Acta Neurologica Belgica

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30-10-2023 | Methotrexate | Letter to the Editor

Intrathecal methotrexate induced subacute combined degeneration of spinal cord like presentation in a patient with acute lymphocytic leukaemia

Authors: Sreela Krishna, Asish Vijayaraghavan, Deepa Susan Joy Philip, Soumya Sundaram, Sajith Sukumaran

Published in: Acta Neurologica Belgica | Issue 2/2024

Excerpt

Dear Editor, …

Pinnix CC, Chi L, Jabbour EJ, Milgrom SA, Smith GL, Daver N, Garg N, Cykowski MD, Fuller G, Cachia D, Kamiya-Matsuoka C, Woodman K, Dinardo C, Jain N, Kadia TM, Pemmaraju N, Ohanian M, Konopleva M, Kantarjian HM, Dabaja BS (2017) Dorsal column myelopathy after intrathecal chemotherapy for leukemia. Am J Hematol 92(2):155–160. https://doi.org/10.1002/ajh.24611.PMID:27874212;PMCID:PMC5338569CrossRefPubMedPubMedCentral

Vezmar S, Schüsseler P, Becker A, Bode U, Jaehde U (2009) Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity. Pediatr Blood Cancer 52(1):26–32. https://doi.org/10.1002/pbc.21827. (PMID: 19006245)CrossRefPubMed

Bidikian AH, Bazarbachi A, Hourani R, El-Cheikh J, Abou DI (2021) Intrathecal methotrexate induced myelopathy, rare yet serious complication: a case report and review of the literature. Curr Res Transl Med. 69(3):103296CrossRefPubMed

Tariq H, Gilbert A, Sharkey FE (2018) Intrathecal methotrexate-induced necrotizing myelopathy: a case report and review of histologic features. Clin Med Insights Pathol 4(11):1179555718809071. https://doi.org/10.1177/1179555718809071.PMID:30450009;PMCID:PMC6236481CrossRef

Title: Intrathecal methotrexate induced subacute combined degeneration of spinal cord like presentation in a patient with acute lymphocytic leukaemia
Authors: Sreela Krishna
Asish Vijayaraghavan
Deepa Susan Joy Philip
Soumya Sundaram
Sajith Sukumaran
Publication date: 30-10-2023
Publisher: Springer International Publishing
Keywords: Methotrexate
Methotrexate
Subacute Combined Degeneration of Spinal Cord
Acute Lymphoblastic Leukemia
Leukemia
Published in: Acta Neurologica Belgica / Issue 2/2024
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-023-02418-4

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Intrathecal methotrexate induced subacute combined degeneration of spinal cord like presentation in a patient with acute lymphocytic leukaemia

Excerpt

Keynote webinar | Spotlight on medication adherence

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