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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2011

Open Access 01-12-2011 | Case report

Metastatic eccrine porocarcinoma: report of a case and review of the literature

Authors: Ugo Marone, Corrado Caracò, Anna Maria Anniciello, Gianluca Di Monta, Maria Grazia Chiofalo, Maria Luisa Di Cecilia, Nicola Mozzillo

Published in: World Journal of Surgical Oncology | Issue 1/2011

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Abstract

Eccrine porocarcinoma (EPC) is a rare type of skin cancer arising from the intraepidermal portion of eccrine sweat glands or acrosyringium, representing 0.005-0.01% of all cutaneous tumors. About 20% of EPC will recur and about 20% will metastasize to regional lymph nodes. There is a mortality rate of 67% in patients with lymph node metastases. Although rare, the occurrence of distant metastases has been reported.
We report a case of patient with EPC of the left arm, with axillary nodal involvement and subsequent local relapse, treated by complete lymph node dissection and electrochemotherapy (ECT).
EPC is an unusual tumor to diagnose. Neither chemotherapy nor radiation therapy has been proven to be of clinical benefit in treating metastatic disease. Although in the current case the short follow-up period is a limitation, we consider in the management of EPC a therapeutic approach involving surgery and ECT, because of its aggressive potential for loregional metastatic spread.
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Literature
1.
Wick MR, Goellner JR, Wolfe JT, Su WP: Adnexal carcinomas of the skin. I. Eccrine carcinomas. Cancer. 1985, 56: 1147-1162. 10.1002/1097-0142(19850901)56:5<1147::AID-CNCR2820560532>3.0.CO;2-3.CrossRefPubMed
2.
3.
Pinkus H, Mehregan AH: Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget's dermatosis. Arch Dermatol. 1963, 88: 597-607.CrossRefPubMed
4.
Mehregan AH, Hashimoto K, Rahbari H: Eccrine adenocarcinoma. A clinicopathologic study of 35 cases. Arch Dermatol. 1983, 119: 104-114. 10.1001/archderm.119.2.104.CrossRefPubMed
5.
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E: Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001, 25: 710-720. 10.1097/00000478-200106000-00002.CrossRefPubMed
6.
McMichael AJ, Gay J: Malignant eccrine poroma in an elderly African-American woman. Dermatol Surg. 1999, 25: 733-735. 10.1046/j.1524-4725.1999.99041.x.CrossRefPubMed
7.
Bleier BS, Newman JG, Quon H, Feldman MD, Kent KK, Wenstein GS: Eccrine prorcarcinoma of the nose: case report and review of world literature. Arch Otolaryngol Head Neck Surg. 2006, 132: 215-218. 10.1001/archotol.132.2.215.CrossRefPubMed
8.
Klenzner T, Arapakis I, Kayser G: Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma. Otolaryngol Head Neck Surg. 2006, 135: 158-160. 10.1016/j.otohns.2005.03.041.CrossRefPubMed
9.
Shiohara J, Koga H, Uhara H, Takata M, Saida T: Eccrine porocarcinoma: clinical and pathological studies of 12 cases. J Dermatol. 2007, 34: 516-522. 10.1111/j.1346-8138.2007.00324.x.CrossRefPubMed
10.
Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology. 2008, 216: 229-233. 10.1159/000112931.CrossRefPubMed
11.
Jain R, Prabhakaran VC, Huilgol SC, Gehling N, James CL, Selva D: Eccrine porocarcinoma of the upper eyelid. Ophthal Plast Reconstr Surg. 2008, 24: 221-223. 10.1097/IOP.0b013e31816e4167.CrossRefPubMed
12.
Mahomed F, Blok J, Grayson W: The suamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases. J Clin Pathol. 2008, 61: 361-365. 10.1136/jcp.2007.049213.CrossRefPubMed
13.
Vandeweyer E, Renorte C, Musette S, Gilles A: Eccrine porocarcinoma: a case report. Acta Chir Belg. 2006, 106: 121-123.PubMed
14.
Shaw M, McKee PH, Lowe D, Black MM: Malignant eccrine poroma: a study of twenty-sweven cases. Br J Dermatol. 1982, 107: 675-680. 10.1111/j.1365-2133.1982.tb00527.x.CrossRefPubMed
15.
Brown CW, Dy LC: Eccrine porocarcinoma. Dermatol Ther. 2008, 433-438. 10.1111/j.1529-8019.2008.00243.x.
16.
Gonzales-Lopez MA, Vasquez-Lopez F, Soler T, Gomez-Diez S, Garzia YH, Manjon JA, Lopez-Escobar M, Perez-Oliva N: Metastatic Eccrine Porocarcinoma: a 5.6 year follow-up study of a patient treated with a combined therapeutic protocol. Dermatol Surg. 2003, 29: 1227-1232. 10.1111/j.1524-4725.2003.29393.x.
17.
De Giorgi V, Sestini S, Massi D, Papi F, Lotti T: Eccrine Porocarcinomna: a rare but sometimes fatal malignant neoplasm. Dermatol Surg. 2007, 33: 374-377. 10.1111/j.1524-4725.2007.33077.x.PubMed
18.
Luz Mde A, Ogata DC, Montenegro MF, Biasi LJ, Ribeiro LC: Eccrine poro carcinoma (malignant eccrine poroma): a series of eight challenging cases. Clinics (Sao Paulo). 2010, 65: 739-742.CrossRef
19.
Goel R, Contos MJ, Wallace ML: Widespread metastatic eccrine porocarcinoma. J Am Acad Dermatol. 2003, 49: 252-254. 10.1016/S0190-9622(03)00444-4.CrossRef
20.
Nouri K, Rivas MP, Pedroso F, Bhatia R, Civantos F: Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinomas of the head and neck. Arch Dermatol. 2004, 140: 1284-10.1001/archderm.140.10.1284-a.CrossRefPubMed
21.
Testori A, Tosti G, Martinoli C, Spadola G, Cataldo F, Verrecchia F, Baldini F, Mosconi M, Soteldo J, Tedeschi I, Passoni C, Pari C, Di Pietro A, Ferrucci PF: Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach. Dermatol Ther. 2010, 23: 651-661. 10.1111/j.1529-8019.2010.01370.x.CrossRefPubMed
Metadata
Title
Metastatic eccrine porocarcinoma: report of a case and review of the literature
Authors
Ugo Marone
Corrado Caracò
Anna Maria Anniciello
Gianluca Di Monta
Maria Grazia Chiofalo
Maria Luisa Di Cecilia
Nicola Mozzillo
Publication date
01-12-2011
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2011
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-9-32

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