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Journal of Neuro-Oncology

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01-04-2019 | Metastasis | Clinical Study

Efficacy of gamma knife radiosurgery in brain metastases of primary gynecological tumors

Authors: Zjiwar H. A. Sadik, Laurens V. Beerepoot, Patrick E. J. Hanssens

Published in: Journal of Neuro-Oncology | Issue 2/2019

Abstract

Objective

Gynecological brain metastases (BM) are rare and usually develop as part of widespread disseminated disease. Despite treatment, the majority of these patients do not survive > 1 year due to advanced extracranial disease. The use of Gamma Knife Radiosurgery (GKRS) for gynecological BM is not well known. The goal of this study is to evaluate the efficacy of GKRS for gynecological BM.

Methods

We performed a retrospective study of patients with gynecological BM who underwent GKRS between 2002 and 2015. A total of 41 patients were included. Outcome measures were local tumor control (LC), development of new BM and/or leptomeningeal disease, overall intracranial progression free survival (PFS) and survival.

Results

LC was 100%, 92%, 80%, 75% and 67% at 3, 6, 9, 12 and 15 months, respectively. PFS was 90%, 61%, 41%, 23% and 13% at 3, 6, 9, 12 and 15 months, respectively. During follow-up (FU), 18 (44%) patients had intracranial progression. Distant BM occurred in 29% of the patients. Local recurrence and distant recurrence occurred after a mean FU time of 15.5 (2.6–71.9) and 11.4 (2–40) months, respectively. Thirty-one (76%) patients died due to extracranial tumor progression and only 2 (5%) patients died due to progressive intracranial disease. The overall mean survival from time of GKRS was 19 months (1–109). The 6-month, 1-year, and 2-year survival rate from the time of GKRS were 71%, 46%, and 22%, respectively.

Conclusion

GKRS is a good treatment option for controlling gynecological BM. As most patients die due to extracranial tumor progression, their survival might improve with better systemic treatment options in addition to GKRS.

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Title: Efficacy of gamma knife radiosurgery in brain metastases of primary gynecological tumors
Authors: Zjiwar H. A. Sadik
Laurens V. Beerepoot
Patrick E. J. Hanssens
Publication date: 01-04-2019
Publisher: Springer US
Keywords: Metastasis
Gynecologic Cancer
Published in: Journal of Neuro-Oncology / Issue 2/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03094-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy of gamma knife radiosurgery in brain metastases of primary gynecological tumors

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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