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Acta Neurochirurgica
Published in: Acta Neurochirurgica 9/2012

Open Access 01-09-2012 | Clinical Article

Gamma knife surgery for brain metastases from ovarian cancer

Authors: Akiyoshi Ogino, Tatsuo Hirai, Takao Fukushima, Toru Serizawa, Takao Watanabe, Atsuo Yoshino, Yoichi Katayama

Published in: Acta Neurochirurgica | Issue 9/2012

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Abstract

Background

Brain metastases from ovarian cancer are rare, but their incidence is increasing. The purpose of this study was to investigate the characteristics of brain metastases from ovarian cancer, and to assess the efficacy of treatment with gamma knife surgery (GKS).

Methods

A retrospective review was performed of patients with brain metastases from ovarian cancer who were treated at the Tokyo Gamma Unit Center from 2006 to 2010.

Results

Sixteen patients were identified. Their median age at diagnosis of brain metastases was 56.5 years, the median interval from diagnosis of ovarian cancer to brain metastases was 27.5 months, and the median number of brain metastases was 2. The median Karnofsky Performance Score (KPS) at the first GKS was 80. The median survival following diagnosis of brain metastases was 12.5 months, and 6-month and 1-year survival rates were 75 % and 50 %, respectively. The tumor control rate was 86.4 %. The KPS (<80 vs ≥80) and total volume of brain metastases (<10 cm3 vs ≥10 cm3) were significantly associated with survival according to a univariate analysis (p = 0.004 and p = 0.02, respectively).

Conclusions

The results of this study suggest that GKS is an effective remedy and acceptable choice for the control of brain metastases from ovarian cancer.
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Metadata
Title
Gamma knife surgery for brain metastases from ovarian cancer
Authors
Akiyoshi Ogino
Tatsuo Hirai
Takao Fukushima
Toru Serizawa
Takao Watanabe
Atsuo Yoshino
Yoichi Katayama
Publication date
01-09-2012
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 9/2012
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-012-1376-3

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