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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 8/2019

Open Access 01-08-2019 | Metastasis | Review Article

The RANK–RANKL axis: an opportunity for drug repurposing in cancer?

Authors: S. Peters, P. Clézardin, I. Márquez-Rodas, D. Niepel, C. Gedye

Published in: Clinical and Translational Oncology | Issue 8/2019

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Abstract

Drug repurposing offers advantages over traditional drug development in terms of cost, speed and improved patient outcomes. The receptor activator of nuclear factor kappa B (RANK) ligand (RANKL) inhibitor denosumab is approved for the prevention of skeletal-related events in patients with advanced malignancies involving bone, including solid tumours and multiple myeloma. Following improved understanding of the role of RANK/RANKL in cancer biology, denosumab has already been repurposed as a treatment for giant cell tumour of bone. Here, we review the role of RANK/RANKL in tumourigenesis, including effects on tumour initiation, progression and metastasis and consider the impact of RANK/RANKL on tumour immunology and immune evasion. Finally, we look briefly at ongoing trials and future opportunities for therapeutic synergy when combining denosumab with anti-cancer agents such as immune checkpoint inhibitors.
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Metadata
Title
The RANK–RANKL axis: an opportunity for drug repurposing in cancer?
Authors
S. Peters
P. Clézardin
I. Márquez-Rodas
D. Niepel
C. Gedye
Publication date
01-08-2019
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 8/2019
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-018-02023-5

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