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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 8/2019

01-08-2019 | Affective Disorder | Brief Research Article

Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study

Authors: C. Calderon, A. Carmona-Bayonas, R. Hernandez, B. Castelo, S. Varma, O. Donnay, D. Gomez, P. Jimenez-Fonseca

Published in: Clinical and Translational Oncology | Issue 8/2019

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Abstract

Background

Our study analyzes the incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer.

Methods

A multi-institutional, prospective, observational study was conducted with 750 participants of 14 hospitals in Spain. Participants’ socio-demographic and clinical characteristics were collected using a standardized self-report form and using EORTC QoL-QLQ-C30, BSI, Mini-MAC questionnaires.

Results

In women, sleep problems, depression and anxious preoccupation were observed in 65, 41 and 21%, respectively. In men, sleep problems, depression and anxious preoccupation were reported in 51, 29 and 61%, respectively. More sleep problems, depression and anxious preoccupation were found among women than males. Depression was a significant predictor of anxious preoccupation. In males, sleep problems partially mediated this association. This was not confirmed in women.

Conclusion

Our findings point toward the importance of developing interventions that decrease depression and sleep problems in cancer.
Literature
1.
Jimenez-Fonseca P, Calderon C, Carmona-Bayonas A, Muñoz MM, Hernández R, Mut Lloret M, et al. The relationship between physician and cancer patient when initiating adjuvant treatment and its association with sociodemographic and clinical variables. Clin Transl Oncol. 2018;20(11):1392–9.CrossRefPubMed
2.
Bower JE. Behavioral symptoms in breast cancer patients and survivors: fatigue, insomnia, depression, and cognitive disturbance. J Clin Oncol. 2008;26(5):768–77.CrossRefPubMedPubMedCentral
3.
Loh KP, Zittel J, Kadambi S, Pandya C, Xu H, Flannery M, et al. Elucidating the associations between sleep disturbance and depression, fatigue, and pain in older adults with cancer. J Geriatr Oncol. 2018;9(5):464–8.CrossRefPubMed
4.
Costa-Requena G, Gil F. The mental adjustment to cancer scale: a psychometric analysis in Spanish cancer patients. Psychooncology. 2009;18(9):984–91.CrossRefPubMed
5.
Innominato PF, Spiegel D, Ulusakarya A, Giacchetti S, Bjarnason GA, Lévi F, et al. Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer. Sleep Med. 2015;16(3):391–8.CrossRefPubMed
6.
Howell D, Oliver TK, Keller-Olaman S, Davidson JR, Garland S, Samuels C, et al. Sleep disturbance in adults with cancer: a systematic review of evidence for best practices in assessment and management for clinical practice. Ann Oncol. 2014;25(4):791–800.CrossRefPubMed
7.
Mota DD, Pimenta CA, Caponero R. Fatigue in colorectal cancer patients: prevalence and associated factors. Rev Lat Am Enferm. 2012;20(3):495–503.CrossRef
8.
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.CrossRef
9.
Derogatis LR, Melisaratos N. The brief symptom inventory: an introductory report. Psychol Med. 1983;13(3):595–605.CrossRefPubMed
10.
Grassi L, Buda P, Cavana L, Annunziata MA, Torta R, Varetto A. Styles of coping with cancer: the Italian version of the Mini-Mental Adjustment to Cancer (Mini-MAC) scale. Psychooncology. 2005;14(2):115–24.CrossRefPubMed
11.
Zhou ES, Clark K, Recklitis CJ, Obenchain R, Loscalzo M. Sleepless from the get go: sleep problems prior to initiating cancer treatment. Int J Behav Med. 2018;25(5):502–16.CrossRefPubMed
12.
Van Onselen C, Paul SM, Lee K, Dunn L, Aouizerat BE, West C, et al. Trajectories of sleep disturbance and daytime sleepiness in women before and after surgery for breast cancer. J Pain Symptom Manage. 2013;45(2):244–60.CrossRefPubMed
13.
Vin-Raviv N, Akinyemiju TF, Galea S, Bovbjerg DH. Sleep disorder diagnoses and clinical outcomes among hospitalized breast cancer patients: a nationwide inpatient sample study. Support Care Cancer. 2018;26(6):1833–40.CrossRefPubMed
14.
İzci F, Sarsanov D, Erdogan Zİ, İlgün AS, Çelebi E, Alço G, et al. Impact of personality traits, anxiety, depression and hopelessness levels on quality of life in the patients with breast cancer. Eur J Breast Health. 2018;14(2):105–11.PubMedPubMedCentral
15.
Ohrnberger J, Fichera E, Sutton M. The relationship between physical and mental health: a mediation analysis. Soc Sci Med. 2017;195:42–9.CrossRefPubMed
Metadata
Title
Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study
Authors
C. Calderon
A. Carmona-Bayonas
R. Hernandez
B. Castelo
S. Varma
O. Donnay
D. Gomez
P. Jimenez-Fonseca
Publication date
01-08-2019
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 8/2019
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-018-02018-2

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