Extremely Aggressive Behavior of a Completely Resected Case of Gallbladder Undifferentiated Carcinoma, Giant Cell Type: a Rare Case with Breast, Neck Nodes, and Subcutaneous Scalp Nodules Metastasis

Excerpt

Gallbladder carcinoma [GBC] is a rare malignancy with an age-adjusted incidence rate of 1.4 per 100,000 population [1]. However, incidence is quite high in northern part of India [2]. Adenocarcinoma is the most common histological variant; however, other histology viz. squamous cell carcinoma, lymphoma has been reported [3]. Undifferentiated carcinoma of gallbladder is an infrequent entity, with aggressive clinical behavior and poor prognosis [4]. Surgery is the cornerstone of therapy and adjuvant therapy is employed for improving local and systemic disease control with limited evidence [5]. Even after completion of therapy, distant metastasis is common particularly to the liver; however, available literature shows the possibility of metastasis to various organs including the orbit, breast, bone, etc. [6‐14]. Here, we present an extremely aggressive case of undifferentiated carcinoma, giant cell type, of the gallbladder which progressed into florid metastases to unusual sites in a very short span of 6 weeks after extended cholecystectomy. …