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Journal of Cancer Research and Clinical Oncology

Published in:

01-05-2019 | Metastasis | Review – Cancer Research

Controlling metastatic cancer: the role of phytochemicals in cell signaling

Authors: Andrea Kapinova, Peter Kubatka, Alena Liskova, Denis Baranenko, Peter Kruzliak, Milan Matta, Dietrich Büsselberg, Bibiana Malicherova, Anthony Zulli, Taeg Kyu Kwon, Eva Jezkova, Dana Blahutova, Pavol Zubor, Jan Danko

Published in: Journal of Cancer Research and Clinical Oncology | Issue 5/2019

Abstract

Purpose

Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation.

Results

Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds.

Conclusions

Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.

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Title: Controlling metastatic cancer: the role of phytochemicals in cell signaling
Authors: Andrea Kapinova
Peter Kubatka
Alena Liskova
Denis Baranenko
Peter Kruzliak
Milan Matta
Dietrich Büsselberg
Bibiana Malicherova
Anthony Zulli
Taeg Kyu Kwon
Eva Jezkova
Dana Blahutova
Pavol Zubor
Jan Danko
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keyword: Metastasis
Published in: Journal of Cancer Research and Clinical Oncology / Issue 5/2019
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-019-02892-5

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