Top

World Journal of Surgery

Published in:

01-06-2021 | Metastasis | Original Scientific Report

Usefulness of Serum Anti-p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

Authors: Kazutaka Kojima, Junichi Shindoh, Miho Akabane, Ryosuke Umino, Yuta Kobayashi, Satoshi Okubo, Masaji Hashimoto

Published in: World Journal of Surgery | Issue 6/2021

Abstract

Background

While anti-p53 antibody (p53-Ab) is a potential marker for early detection of colorectal cancer, its clinical utility in patients with advanced colorectal cancer remains unknown.

Methods

The clinical significance of p53-Ab was investigated by analyzing the data of 206 patients who underwent curative resection for colorectal liver metastases.

Results

Of the 206 patients, 60 (29%) were seropositive and 146 were seronegative for p53-Ab before the surgery. The preoperative serum p53-Ab level showed no significant correlation with the serum CEA or serum CA19-9 levels. The perioperative changes in serum p53-Ab positivity were significantly correlated with the preoperative serum p53-Ab levels and multivariate analysis confirmed that a higher preoperative p53-Ab level was independently associated with a worse recurrence-free survival (hazard ratio [HR], 1.07; 95% CI, 1.01–1.13; P = 0.033 per + 100 U/mL), even after adjustments for other oncological factors, including the preoperative serum CEA level.

Conclusion

Higher preoperative p53-Ab levels were associated with a higher risk of recurrence after curative resection of colorectal liver metastases.

Available only for authorised users

Kopetz S, Chang GJ, Overman MJ, Eng C, Sargent DJ, Larson DW et al (2009) Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 27(22):3677–3683PubMedPubMedCentral

Adam R, De Gramont A, Figueras J, Guthrie A, Kokudo N, Kunstlinger F et al (2012) The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist 17(10):1225–1239CrossRefPubMedPubMedCentral

Park IJ, Choi GS, Lim KH, Kang BM, Jun SH (2009) Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level. Ann Surg Oncol 16(11):3087–3093CrossRefPubMed

Bhatti I, Patel M, Dennison AR, Thomas MW, Garcea G (2015) Utility of postoperative CEA for surveillance of recurrence after resection of primary colorectal cancer. Int J Surg 16(Pt A):123–128CrossRefPubMed

Hammel P, Leroy-Viard K, Chaumette MT, Villaudy J, Falzone MC, Rouillard D et al (1999) Correlations between p53-protein accumulation, serum antibodies and gene mutation in colorectal cancer. Int J Cancer 81(5):712–718CrossRefPubMed

Liu S, Tan Q, Song Y, Shi Y, Han X (2020) Anti-p53 autoantibody in blood as a diagnostic biomarker for colorectal cancer: a meta-analysis. Scand J Immunol 91(2):e12829PubMed

Suppiah A, Greenman J (2013) Clinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancer. World J Gastroenterol 19(29):4651–4670CrossRefPubMedPubMedCentral

Kressner U, Glimelius B, Bergstrom R, Pahlman L, Larsson A, Lindmark G (1998) Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal cancer. Br J Cancer 77(11):1848–1851CrossRefPubMedPubMedCentral

Yamaguchi T, Takii Y, Maruyama S (2014) Usefulness of serum p53 antibody measurement in colorectal cancer: an examination of 1384 primary colorectal cancer patients. Surg Today 44(8):1529–1535CrossRefPubMed

10.

Shindoh J, Nishioka Y, Yoshioka R, Sugawara T, Sakamoto Y, Hasegawa K et al (2016) KRAS mutation status predicts site-specific recurrence and survival after resection of colorectal liver metastases irrespective of location of the primary lesion. Ann Surg Oncol 23(6):1890–1896CrossRefPubMed

11.

Suzuki T, Shimada H, Ushigome M, Koike J, Funahashi K, Nemoto T et al (2016) Three-year monitoring of serum p53 antibody during chemotherapy and surgery for stage IV rectal cancer. Clin J Gastroenterol 9(2):55–58CrossRefPubMed

12.

Abe S, Kawai K, Ishihara S, Nozawa H, Hata K, Kiyomatsu T et al (2017) Prognostic value of pre- and postoperative anti-p53 antibody levels in colorectal cancer patients: a retrospective study. Oncology 92(1):31–38CrossRefPubMed

13.

Tang R, Yeh CY, Wang JY, Changchien CR, Chen JS, Hsieh LL (2009) Serum p53 antibody as tumor marker for follow-up of colorectal cancer after curative resection. Ann Surg Oncol 16(9):2516–2523CrossRefPubMed

14.

Chang SC, Lin JK, Lin TC, Liang WY (2005) Genetic alteration of p53, but not overexpression of intratumoral p53 protein, or serum p53 antibody is a prognostic factor in sporadic colorectal adenocarcinoma. Int J Oncol 26(1):65–75PubMed

15.

Shiota G, Ishida M, Noguchi N, Oyama K, Takano Y, Okubo M et al (2000) Circulating p53 antibody in patients with colorectal cancer: relation to clinicopathologic features and survival. Dig Dis Sci 45(1):122–128CrossRefPubMed

Title: Usefulness of Serum Anti-p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases
Authors: Kazutaka Kojima
Junichi Shindoh
Miho Akabane
Ryosuke Umino
Yuta Kobayashi
Satoshi Okubo
Masaji Hashimoto
Publication date: 01-06-2021
Publisher: Springer International Publishing
Keywords: Metastasis
Colorectal Cancer
Colorectal Cancer
Published in: World Journal of Surgery / Issue 6/2021
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-021-06049-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Usefulness of Serum Anti-p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 6/2021

Correction to: The Issues of Post-Lichtenstein Chronic Groin Pain

Surgical Outcome of Pancreaticoduodenectomy in Patients with a History of Roux-en-Y Reconstruction after Tumor Removal

Authors’ Reply: Patient Outcomes Following Emergency Bowel Resection for Inflammatory Bowel Disease and the Impact of Surgical Subspecialisation in the North of England: A Retrospective Cohort Study

Male Patients may be More Vulnerable to Acute Kidney Injury After Colorectal Surgery in an Enhanced Recovery Program: A Propensity Score Matching Analysis

Revisiting Amyand’s Hernia: A 20-Year Systematic Review

iTriangular Stapling Technique: A Novel Reconstruction Method and Clinical Outcomes of Cervical Esophagogastric Anastomosis after Esophagectomy