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Cancer Cell International
Published in: Cancer Cell International 1/2021

Open Access 01-12-2021 | Metastasis | Review

Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Authors: Qian Lu, Jun Lou, Ruyun Cai, Weidong Han, Hongming Pan

Published in: Cancer Cell International | Issue 1/2021

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Abstract

Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of human diseases, especially cancers. SBF2-AS1, a newly identified long non-coding RNA, has been verified to be highly expressed in diversiform cancers, and is involved in processes promoting tumorigenesis, tumor progression and tumor metastasis. Moreover, upregulation of SBF2-AS1 expression was significantly related to disadvantageous clinicopathologic characteristics and indicated poor prognosis. In this review, we comprehensively summarize the up-to-date knowledge of the detailed mechanisms and underlying functions of SBF2-AS1 in diverse cancer types, highlighting the potential of SBF2-AS1 as a diagnostic and prognostic biomarker and even a therapeutic target.
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Metadata
Title
Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
Authors
Qian Lu
Jun Lou
Ruyun Cai
Weidong Han
Hongming Pan
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2021
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-021-02123-3

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