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World Journal of Surgery

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01-05-2017 | Original Scientific Report

Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia

Authors: Arda Isik, Cebrail Gursul, Kemal Peker, Merve Aydın, Deniz Fırat, İsmayil Yılmaz

Published in: World Journal of Surgery | Issue 5/2017

Abstract

Aim

The aim of this prospective study is to investigate if there is a relationship between inguinal hernia, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs).

Materials and methods

This case control study was performed on patients admitted to the general surgery department of Erzincan University Hospital. Four groups were created: control, indirect hernia, direct hernia, and bilateral hernia. All groups were comprised of 11 patients. Serum and tissue levels of MMP-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3, and hydroxyproline were evaluated.

Results

MMPs values were significantly high at hernia groups, especially at bilateral hernia group (p < 0.05), whereas TIMPs values were significantly low at bilateral hernia group (p < 0.05). MMPs values were increasing at hernia groups in an order as control, indirect, direct, and bilateral. TIMPs values were decreasing at hernia groups in an order as control, indirect, direct, and bilateral.

Conclusion

Increased levels of MMP-1-2-9-13 and decreased levels of TIMP-1-2-3 may have played role in the formation of inguinal hernia. Hernia is not only a local defect, but a reflection of systemic disease. This is even more significant for bilateral hernias.

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Title: Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia
Authors: Arda Isik
Cebrail Gursul
Kemal Peker
Merve Aydın
Deniz Fırat
İsmayil Yılmaz
Publication date: 01-05-2017
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 5/2017
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-016-3858-6

At a glance: The STEP trials

Springer Medicine

Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia

Abstract

Aim

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Aim

Materials and methods

Results

Conclusion

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