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Published in: Digestive Diseases and Sciences 4/2007

01-04-2007 | Case Report

Metachronous Small Bowel Adenocarcinomas Detected by Capsule Endoscopy in a Patient with Hereditary Nonpolyposis Colorectal Cancer

Authors: Matthew M. Baichi, Razi M. Arifuddin, Parvez S. Mantry

Published in: Digestive Diseases and Sciences | Issue 4/2007

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Excerpt

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common colorectal cancer susceptibility syndrome, with a lifetime risk of colon cancer of 80% [1]. Affected individuals are at risk for extracolonic malignancies as well. These include (in descending order) endometrial, ovarian, gastric, and transition cell carcinoma of the uroepithelial tract. Other more rare HNPCC-associated extracolonic tumors include pancreas, hepatobiliary, brain, skin, and possibly small bowel. …
Literature
1.
go back to reference DeFrancisco J, Grady WM (2003) Diagnosis and management of hereditary non-polyposis colon cancer. Gastrointest Endosc 58:390–408PubMedCrossRef DeFrancisco J, Grady WM (2003) Diagnosis and management of hereditary non-polyposis colon cancer. Gastrointest Endosc 58:390–408PubMedCrossRef
2.
go back to reference Vasen HFA, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G, Nagengast FM, Meijers-Heijboer EH, Bertario L, Varesco L, Bisgaard M, Mohr J, Fodde R, Khan PM (1996) Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 110:1020–1027PubMedCrossRef Vasen HFA, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G, Nagengast FM, Meijers-Heijboer EH, Bertario L, Varesco L, Bisgaard M, Mohr J, Fodde R, Khan PM (1996) Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 110:1020–1027PubMedCrossRef
3.
go back to reference Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, De la Chapelle A, Peltomaki P, Mecklin JP, Jarvinen HJ (1999) Cancer risk in mutation carriers of dna-mismatch-repair genes. Int J Cancer 81:214–218PubMedCrossRef Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, De la Chapelle A, Peltomaki P, Mecklin JP, Jarvinen HJ (1999) Cancer risk in mutation carriers of dna-mismatch-repair genes. Int J Cancer 81:214–218PubMedCrossRef
4.
go back to reference Schulmann K, Brasch FE, Kunstmann E, Engel C, Pagenstecher C, Vogelsang H, Kruger S, Vogel T, Knaebel HP, Ruschoff J, Hahn SA, Knebel-Doeberitz MV, Moeslein G, Meltzer SJ, Schackert HK, Tympner C, Mangold E, Schmiegel W (2005) HNPCC-associated small bowel cancer: clinical and molecular characteristics. Gastroenterology 128:590–599PubMedCrossRef Schulmann K, Brasch FE, Kunstmann E, Engel C, Pagenstecher C, Vogelsang H, Kruger S, Vogel T, Knaebel HP, Ruschoff J, Hahn SA, Knebel-Doeberitz MV, Moeslein G, Meltzer SJ, Schackert HK, Tympner C, Mangold E, Schmiegel W (2005) HNPCC-associated small bowel cancer: clinical and molecular characteristics. Gastroenterology 128:590–599PubMedCrossRef
5.
go back to reference Rodriguez-Bigas MA, Vasen HFA, Lynch HT, Watson P, Myrhoj T, Jarvinen HJ, Mecklin JP, Macrae F, St John DJB, Bertario L, Fidalgo P, Madlensky L, Rozen P (1998) Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. Cancer 83:240–244PubMedCrossRef Rodriguez-Bigas MA, Vasen HFA, Lynch HT, Watson P, Myrhoj T, Jarvinen HJ, Mecklin JP, Macrae F, St John DJB, Bertario L, Fidalgo P, Madlensky L, Rozen P (1998) Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. Cancer 83:240–244PubMedCrossRef
6.
go back to reference Lynch HT, Smyrk TC, Lynch PM, Lanspa SJ, Boman BM, Ens J, Lynch JF, Strayhorn P, Carmody T, Christofaro G (1989) Adenocarcinoma of the small bowel in lynch syndrome 2. Cancer 64:2178–2183PubMedCrossRef Lynch HT, Smyrk TC, Lynch PM, Lanspa SJ, Boman BM, Ens J, Lynch JF, Strayhorn P, Carmody T, Christofaro G (1989) Adenocarcinoma of the small bowel in lynch syndrome 2. Cancer 64:2178–2183PubMedCrossRef
7.
go back to reference Benatti P, Roncucci L, Percesepe A, Viel A, Pedroni M, Tamassia MG, Vaccina F, Fante R, De Pietri S, Ponz de Leon M (1998) Small bowel carcinoma in hereditary nonpolyposis colorectal cancer. Am J Gastroenterol 93:2219–2222PubMedCrossRef Benatti P, Roncucci L, Percesepe A, Viel A, Pedroni M, Tamassia MG, Vaccina F, Fante R, De Pietri S, Ponz de Leon M (1998) Small bowel carcinoma in hereditary nonpolyposis colorectal cancer. Am J Gastroenterol 93:2219–2222PubMedCrossRef
8.
go back to reference Pennazio M, Arrigoni A, Rossini FP (1999) Enteroscopic identification of an adenocarcinoma of the small bowel in a patient with previously unrecognized hereditary nonpolyposis colorectal cancer syndrome. Am J Gastroenterol 94:1962–1966PubMedCrossRef Pennazio M, Arrigoni A, Rossini FP (1999) Enteroscopic identification of an adenocarcinoma of the small bowel in a patient with previously unrecognized hereditary nonpolyposis colorectal cancer syndrome. Am J Gastroenterol 94:1962–1966PubMedCrossRef
9.
go back to reference Melmed GY, Lo SK (2005) Capsule endoscopy: practical applications. Clin Gastroenterol Hepatol 3:411–422PubMedCrossRef Melmed GY, Lo SK (2005) Capsule endoscopy: practical applications. Clin Gastroenterol Hepatol 3:411–422PubMedCrossRef
10.
go back to reference Hewllet A, Hoogerwerf WA, Nealon W, Raju GS, Finlay D, Nath SK (2004) Capsule endoscopic diagnosis of a localized small bowel cancer missed by enteroclysis in a patient with HNPCC. Am J Gastroenterol 99:s161, abstr 495 Hewllet A, Hoogerwerf WA, Nealon W, Raju GS, Finlay D, Nath SK (2004) Capsule endoscopic diagnosis of a localized small bowel cancer missed by enteroclysis in a patient with HNPCC. Am J Gastroenterol 99:s161, abstr 495
11.
go back to reference Chow JS, Chen CC, Ahsan H, Neugut AI (1996) A population-based study of the incidence of malignant small bowel tumours: SEER, 1973-1990. Int J Epidemiol 25:722–728PubMedCrossRef Chow JS, Chen CC, Ahsan H, Neugut AI (1996) A population-based study of the incidence of malignant small bowel tumours: SEER, 1973-1990. Int J Epidemiol 25:722–728PubMedCrossRef
12.
go back to reference Howe JR, Karnell LH, Menck HR, Scott-Conner C (1999) Adenocarcinoma of the small bowel. Cancer 86:2693–2706PubMedCrossRef Howe JR, Karnell LH, Menck HR, Scott-Conner C (1999) Adenocarcinoma of the small bowel. Cancer 86:2693–2706PubMedCrossRef
13.
go back to reference Dabaja BS, Suki D, Pro B, Bonnen M, Ajani J (2004) Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcomes of 217 patients. Cancer 101:518–526PubMedCrossRef Dabaja BS, Suki D, Pro B, Bonnen M, Ajani J (2004) Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcomes of 217 patients. Cancer 101:518–526PubMedCrossRef
14.
go back to reference Hartman D, Schmidt H, Bolz G, Schilling D, Kinzel F, Eickhoff A, Huschner W, Moller K, Jakobs R, Reitzig P, Weickert U, Gellert K, Schulz H, Guenther K, Hollerbuhl H, Schoenleben K, Schulz H, Riemann JF (2005) A prospective two-enter study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding. Gastrointest Endosc 61:826–832CrossRef Hartman D, Schmidt H, Bolz G, Schilling D, Kinzel F, Eickhoff A, Huschner W, Moller K, Jakobs R, Reitzig P, Weickert U, Gellert K, Schulz H, Guenther K, Hollerbuhl H, Schoenleben K, Schulz H, Riemann JF (2005) A prospective two-enter study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding. Gastrointest Endosc 61:826–832CrossRef
15.
go back to reference Pennazio M, Santucci R, Rondonotti E, Abbiati C, Beccari G, Rossini FP, DeFranchis R (2004) Outcomes of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. Gastroenterology 126:643– 653PubMedCrossRef Pennazio M, Santucci R, Rondonotti E, Abbiati C, Beccari G, Rossini FP, DeFranchis R (2004) Outcomes of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. Gastroenterology 126:643– 653PubMedCrossRef
16.
go back to reference Viazis N, Papaxoinis K, Theodoropoulos I, Sgouros S, Vlachogiannakos J, Pipis P, Markoglou C, Avgerinos A (2005) Impact of capsule endoscopy in obscure small-bowel bleeding: defining strict diagnostic criteria for a favorable outcome. Gastrointest Endosc 62:717–722PubMedCrossRef Viazis N, Papaxoinis K, Theodoropoulos I, Sgouros S, Vlachogiannakos J, Pipis P, Markoglou C, Avgerinos A (2005) Impact of capsule endoscopy in obscure small-bowel bleeding: defining strict diagnostic criteria for a favorable outcome. Gastrointest Endosc 62:717–722PubMedCrossRef
Metadata
Title
Metachronous Small Bowel Adenocarcinomas Detected by Capsule Endoscopy in a Patient with Hereditary Nonpolyposis Colorectal Cancer
Authors
Matthew M. Baichi
Razi M. Arifuddin
Parvez S. Mantry
Publication date
01-04-2007
Published in
Digestive Diseases and Sciences / Issue 4/2007
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9395-7

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